University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia.
Environ Pollut. 2011 Mar;159(3):677-84. doi: 10.1016/j.envpol.2010.11.027. Epub 2010 Dec 24.
This report presents an exhaustive literature review of data on the effect of nanoparticulate TiO(2) on algae, higher plants, aquatic and terrestrial invertebrates and freshwater fish. The aim, to identify the biologically important characteristics of the nanoparticles that have most biological significance, was unsuccessful, no discernable correlation between primary particle size and toxic effect being apparent. Secondary particle size and particle surface area may be relevant to biological potential of nanoparticles, but insufficient confirmatory data exist. The nanotoxicity data from thirteen studies fail to reveal the characteristics actually responsible for their biological reactivity because reported nanotoxicity studies rarely carry information on the physicochemical characteristics of the nanoparticles tested. A number of practical measures are suggested which should support the generation of reliable QSAR models and so overcome this data inadequacy.
本报告对纳米 TiO(2) 对藻类、高等植物、水生和陆生无脊椎动物以及淡水鱼类影响的数据进行了全面的文献回顾。本研究旨在确定具有最重要生物学意义的纳米颗粒的生物学特性，但未能成功，因为初级粒径与毒性效应之间没有明显的相关性。次级粒径和颗粒表面积可能与纳米颗粒的生物潜能有关，但现有确认数据不足。13 项研究的纳米毒性数据未能揭示导致其生物反应性的特征，因为报告的纳米毒性研究很少提供有关所测试的纳米颗粒的物理化学特性的信息。本研究提出了一些实用措施，这应有助于生成可靠的定量构效关系模型，从而克服这一数据不足。
