Chaudhary A, Singla S K, Tandon C
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan-173 215, India.
Indian J Pharm Sci. 2010 May;72(3):340-5. doi: 10.4103/0250-474X.70480.
Urinary stones are one of the oldest and the most common afflictions in humans. This disease has tormented humans since the earliest records of civilization. Ten percent of men and 3 % of women have a stone during their adult lives. Calcium containing stones are the most common comprising about 75 % of all urinary calculi, which may be in the form of pure calcium oxalate (50 %) or calcium phosphate (5 %) or a mixture of both (45 %). A number of plants have been mentioned in the Indian ayurvedic system, which plays a vital role in the inhibition of kidney stones. In the present study, the inhibitory potency of crude extracts or fractions of successive solvent extractions of Terminalia arjuna bark was evaluated on various stages of formation of calcium phosphate and on the growth of calcium oxalate monohydrate crystals in vitro. Results obtained indicated that Terminalia arjuna bark has the potential to inhibit the formation of both calcium phosphate and calcium oxalate crystals in vitro. Butanol fraction of Terminalia arjuna extract was the most effective in inhibiting formation of calcium phosphate and calcium oxalate crystals in vitro.
尿路结石是人类最古老且最常见的疾病之一。自文明的最早记录以来，这种疾病就一直折磨着人类。10%的男性和3%的女性在成年期会患结石。含钙结石最为常见，约占所有尿路结石的75%，其可能为纯草酸钙（50%）、磷酸钙（5%）或两者的混合物（45%）的形式。印度阿育吠陀体系中提到了许多植物，其在抑制肾结石方面起着至关重要的作用。在本研究中，对Terminalia arjuna树皮连续溶剂提取物的粗提物或馏分在磷酸钙形成的各个阶段以及一水合草酸钙晶体体外生长的抑制效力进行了评估。所得结果表明，Terminalia arjuna树皮具有在体外抑制磷酸钙和草酸钙晶体形成的潜力。Terminalia arjuna提取物的丁醇馏分在体外抑制磷酸钙和草酸钙晶体形成方面最为有效。
