NOXO1β PX结构域的主链1H、15N和13C共振归属
Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain.
作者信息
Davis Nicole Y, McPhail Linda C, Horita David A
机构信息
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
出版信息
Biomol NMR Assign. 2011 Oct;5(2):139-41. doi: 10.1007/s12104-010-9286-x. Epub 2010 Dec 28.
NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47(phox). NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of the NADPH oxidase complex. These PX domains bind to membrane lipids and target the protein to membranes, recruiting other cytosolic components to the membrane bound components and aiding formation of a active enzyme complex. This recruitment represents a level of regulation of these oxidases. Here we report the backbone assignments of NOXO1β PX.
NOXO1（Nox 组织者 1）是烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶蛋白 p47（phox）的同源物。NADPH 氧化酶将电子从 NADPH 转移到分子氧，生成超氧阴离子。NOXO1 包含一个 N 端 PX（phox 同源）结构域，是在 NADPH 氧化酶复合体胞质亚基中发现的几种含 PX 结构域的蛋白质之一。这些 PX 结构域与膜脂结合，将蛋白质靶向到膜上，将其他胞质成分募集到膜结合成分上，并有助于形成活性酶复合体。这种募集代表了对这些氧化酶的一种调节水平。在此，我们报告了 NOXO1β PX 的主链归属。
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