Department of Chemistry and Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Macromol Biosci. 2012 Jan;12(1):29-39. doi: 10.1002/mabi.201100355. Epub 2011 Dec 15.
Nucleic acids and proteins, two of nature's biopolymers, assemble into complex structures to achieve desired biological functions and inspire the design of synthetic macromolecules containing a wide variety of noncovalent interactions including electrostatics and hydrogen bonding. Researchers have incorporated DNA nucleobases into a wide variety of synthetic monomers/polymers achieving stimuli-responsive materials, supramolecular assemblies, and well-controlled macromolecules. Recently, scientists utilized both electrostatics and complementary hydrogen bonding to orthogonally functionalize a polymer backbone through supramolecular assembly. Diverse macromolecules with noncovalent interactions will create materials with properties necessary for biomedical applications.
核酸和蛋白质，作为两种天然生物聚合物，通过组装形成复杂结构来实现所需的生物功能，并启发了含有多种非共价相互作用（包括静电相互作用和氢键）的合成大分子的设计。研究人员已经将 DNA 碱基整合到各种合成单体/聚合物中，从而获得了对刺激有响应的材料、超分子组装体和可控的大分子。最近，科学家们利用静电作用和互补氢键通过超分子组装对聚合物主链进行正交功能化。具有非共价相互作用的各种大分子将创造出具有生物医学应用所需性能的材料。
