Marshall D A, Mertz P M, Eaglstein W H
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Fla.
Arch Surg. 1990 Sep;125(9):1136-9. doi: 10.1001/archsurg.1990.01410210062009.
We studied the effect of different occlusive dressings and of air exposure on the growth of four pathogenic bacteria in wounds. Partial-thickness wounds on domestic pigs were inoculated with Staphylococcus aureus, Clostridium perfringens, Bacteroides fragilis, or Pseudomonas aeruginosa. Each wound was covered with three dressings (DuoDERM, Opsite, or Vigilon), or left exposed to air. Groups of wounds were sampled at 24, 48, and 72 hours. Staphylococcus aureus reached high levels beneath all of the dressings and in the air-exposed wounds. The numbers of C perfringens and B fragilis were greatly reduced in the air-exposed wounds and slightly reduced in the Opsite-covered wounds. The numbers of P aeruginosa were greatest in the Opsite- and Vigilon-covered wounds. The results indicate that occlusive dressings are not indicated in wounds that clinically appear to be grossly contaminated or that may contain anaerobic organisms.
我们研究了不同的封闭性敷料以及暴露于空气中对伤口内四种病原菌生长的影响。在家猪身上制造了部分厚度的伤口，并接种了金黄色葡萄球菌、产气荚膜梭菌、脆弱拟杆菌或铜绿假单胞菌。每个伤口覆盖三种敷料（多爱肤、 Opsite或Vigilon）之一，或暴露于空气中。在24、48和72小时对多组伤口进行采样。在所有敷料覆盖的伤口以及暴露于空气中的伤口内，金黄色葡萄球菌都达到了很高的数量。暴露于空气中的伤口内产气荚膜梭菌和脆弱拟杆菌的数量大幅减少，而在覆盖Opsite敷料的伤口内则略有减少。在覆盖Opsite和Vigilon敷料的伤口内，铜绿假单胞菌的数量最多。结果表明，对于临床上看似严重污染或可能含有厌氧菌的伤口，不建议使用封闭性敷料。
