Taniguchi Fuminori, Kaponis Apostolos, Izawa Masao, Kiyama Tomoiki, Deura Imari, Ito Masayuki, Iwabe Tomio, Adonakis George, Terakawa Naoki, Harada Tasuku
Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.
Front Biosci (Elite Ed). 2011 Jan 1;3(2):648-62. doi: 10.2741/e277.
Apoptosis is a distinctive form of programmed cell death resulting in the efficient elimination of cells without eliciting an inflammatory response. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid apoptosis outside the uterus. Apoptosis plays a fundamental role for the pathogenesis of endometriosis. Eutopic endometrium from women with endometriosis has increased expression of anti-apoptotic factor and decreased expression of pro-apoptotic factors compared with endometrium from healthy women. These differences could contribute to the survival of regurgitating endometrial cells into the peritoneal cavity and development of endometriosis. Increased apoptosis of Fas-bearing immune cells in the peritoneal cavity may leads to their decreased scavenger activity that eventually results in prolonged survival of ectopic endometrial cells in women with endometriosis. This study is a current review of the literatures focused on the physiological role of apoptosis in normal endometrium and alterations in regulation of apoptosis in eutopic and ectopic endometrium from women with endometriosis. The role of apoptosis in the treatment of endometriosis is also reviewed.
细胞凋亡是一种独特的程序性细胞死亡形式，可有效清除细胞而不引发炎症反应。子宫内膜异位症的特征是子宫外存在具有避免细胞凋亡能力的子宫内膜细胞。细胞凋亡在子宫内膜异位症的发病机制中起重要作用。与健康女性的子宫内膜相比，患有子宫内膜异位症女性的在位内膜抗凋亡因子表达增加，促凋亡因子表达减少。这些差异可能有助于反流至腹腔的子宫内膜细胞存活并发展为子宫内膜异位症。腹腔中携带Fas的免疫细胞凋亡增加可能导致其清除活性降低，最终导致子宫内膜异位症女性异位子宫内膜细胞的存活时间延长。本研究是对当前文献的综述，重点关注细胞凋亡在正常子宫内膜中的生理作用以及子宫内膜异位症女性在位和异位内膜细胞凋亡调控的改变。同时也综述了细胞凋亡在子宫内膜异位症治疗中的作用。
