Cappello Francesco, David Sabrina, Peri Giovanni, Farina Felicia, Conway de Macario Everly, Macario Alberto J L, Zummo Giovanni
Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.
Front Biosci (Schol Ed). 2011 Jan 1;3(1):341-51. doi: 10.2741/s155.
Quantitative changes in Hsp60 during the development of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation is still incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research. It is clear that elucidating the mechanisms by which the chaperonin arrives at these various locations, and characterizing its functions in each of them will provide information useful for understanding carcinogenesis and for developing diagnostic and therapeutic tools for clinical oncology. Some of these issues pertinent to colorectal cancer (CRC) are discussed in this article.
某些肿瘤发生发展过程中Hsp60的定量变化表明，这种伴侣蛋白在肿瘤发生中发挥作用。Hsp60在肿瘤细胞生长和增殖中具体作用的描述仍不完整，但很明显，监测其在组织和体液中的水平及分布在肿瘤诊断、分期、评估预后和治疗反应方面具有潜力。尽管Hsp60被认为是一种线粒体内蛋白，但已在胞质溶胶、细胞膜、囊泡、细胞表面、细胞外空间和血液中被证实存在。Hsp60在所有这些位置出现这一认识为基础研究和应用研究开辟了新途径。显然，阐明伴侣蛋白到达这些不同位置的机制，并确定其在每个位置的功能，将为理解肿瘤发生以及开发临床肿瘤学诊断和治疗工具提供有用信息。本文将讨论其中一些与结直肠癌（CRC）相关的问题。
