Department of Dentistry, Taubaté University, Taubaté -SP - Brazil.
Med Oral Patol Oral Cir Bucal. 2011 Sep 1;16(6):e716-21.
The purpose of this study was to evaluate the effect of Chamomilla recutita on the healing of ulcers in rats.
A 5-mm wound was inflicted on the tongue of 36 rats. Treatment group animals were treated topically with 0.04 mL/day of chamomile ointment, whereas control group animals were not treated. Animals were sacrificed after 3, 7 or 10 days. Semi-quantitative analysis of the degree of inflammation, fibroblast count and wound size was performed, as well as histometric analysis of re-epithelialization and percentage of collagen fibers of the lesion.
Animals treated with chamomile showed the best results regarding epithelialization and percentage of collagen fibers after 10 days. As expected, time had a statistically significant effect (p < 0.05) on fibroblast count, epithelialization, inflammation and wound size; animals sacrificed at 3 days showed the worst results.
Chamomile stimulated re-epithelialization and the formation of collagen fibers after 10 days of treatment; it did not, however, influence inflammation or fibroblast count.
本研究旨在评估春黄菊（Chamomilla recutita）对大鼠溃疡愈合的影响。
在 36 只大鼠舌头上造成 5mm 的创伤。治疗组动物每天局部用 0.04ml 的春黄菊软膏治疗，而对照组动物不治疗。动物在 3、7 或 10 天后被处死。对炎症程度、成纤维细胞计数和伤口大小进行半定量分析，并对病变的上皮再形成和胶原纤维百分比进行组织计量学分析。
用春黄菊治疗的动物在 10 天后在上皮形成和胶原纤维百分比方面表现出最好的结果。正如预期的那样，时间对成纤维细胞计数、上皮形成、炎症和伤口大小有统计学意义（p<0.05）；在 3 天处死的动物表现出最差的结果。
春黄菊在治疗 10 天后刺激上皮再形成和胶原纤维的形成；然而，它并不影响炎症或成纤维细胞计数。
