Division Veterinary Pharmacology & Toxicology, Department Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012, Bern, Switzerland.
Department of Livestock Sciences, Research Institute of Organic Agriculture (FiBL), Ackerstrasse 113, Postbox 219, 5070, Frick, Switzerland.
BMC Vet Res. 2019 May 27;15(1):174. doi: 10.1186/s12917-019-1854-4.
BACKGROUND: Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematically evaluate based on recent scientific literature, the potential of four medicinal plants to enrich the therapeutic options in pyoderma, canine atopic dermatitis, otitis externa, wounds and dermatophytosis in dogs. RESULTS: Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold), Hypericum perforatum L. agg. (St. John's Wort), Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia officinalis L. (Sage). According to the PRISMA statement through literature research on two online databases a total of 8295 publications was screened and narrowed down to a final 138 publications for which full-text documents were analyzed for its content resulting in a total of 145 references (21 clinical, 24 in vivo and 100 in vitro references). CONCLUSIONS: All four plants were proven to have antibacterial and antifungal effects of a rather broad spectrum including antibiotic-resistant bacteria. This makes them an interesting new option for the treatment of pyoderma, otitis externa, infected wounds and dermatophytosis. Marigold, St. John's Wort and Chamomile showed wound-healing properties and are thus promising candidates in line to fill the therapeutic gap in canine wound-healing agents. St. John's Wort and Chamomile also showed anti-inflammatory and other beneficial effects on healthy skin. Due to the wide range of beneficial effects of these medicinal plants, they should be taken into account for the treatment of dermatologic diseases in dogs at least in future clinical research.
背景：几个世纪以来，药用植物一直被用于人类和动物的伤口护理和皮肤病治疗。皮肤病是主人带狗去看兽医的最常见原因之一。这些疾病的治疗和预防需求广泛。涉及的细菌范围很广，包括抗生素耐药菌，这使得治疗具有挑战性，并具有人与动物共患的潜力。本综述的目的是根据最近的科学文献系统评估四种药用植物在犬脓皮病、犬特应性皮炎、外耳炎、伤口和皮肤真菌病中的治疗潜力。
结果：基于四本书和对专门从事植物疗法的兽医的调查，选择了四种药用植物作为本系统评价的主题：金盏花（Calendula officinalis L.）、贯叶连翘（Hypericum perforatum L. agg.）、母菊（Matricaria chamomilla L.，又名母菊（Matricaria recutita L.）、甘菊）和鼠尾草（Salvia officinalis L.）。根据 PRISMA 声明，通过对两个在线数据库的文献研究，共筛选出 8295 篇出版物，并将其缩小到最终的 138 篇全文文献进行分析，共得出 145 篇参考文献（21 篇临床文献、24 篇体内文献和 100 篇体外文献）。
结论：所有四种植物都被证明具有广谱的抗菌和抗真菌作用，包括抗生素耐药菌。这使它们成为治疗脓皮病、外耳炎、感染性伤口和皮肤真菌病的一个有趣的新选择。金盏花、贯叶连翘和甘菊具有伤口愈合特性，因此是犬伤口愈合剂治疗空白的有希望的候选物。贯叶连翘和甘菊也对健康皮肤具有抗炎和其他有益作用。由于这些药用植物具有广泛的有益作用，因此它们应该在未来的临床研究中至少被考虑用于治疗犬的皮肤病。
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