1,25-二羟基维生素D3对干扰素-γ诱导的HEp-2细胞MHC II类分子表达的差异增强作用
Differential enhancement of interferon-gamma-induced MHC class II expression of HEp-2 cells by 1,25-dihydroxyvitamin D3.
作者信息
Tamaki K, Nakamura K
机构信息
Department of Dermatology, Yamanashi Medical College, Japan.
出版信息
Br J Dermatol. 1990 Sep;123(3):333-8. doi: 10.1111/j.1365-2133.1990.tb06293.x.
Interferon-gamma (IFN-gamma) induces the expression of MHC class II antigens on non-lymphoid cells. In this study we investigated the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN-gamma-induced expression of MHC class II antigens on HEp-2 cells. We found that 1,25(OH)2D3 enhanced the IFN-gamma-induced expression of HLA-DR on these cells. Differential effects on the MHC class II antigens HLA-DR, -DQ and -DP were also observed.
γ干扰素（IFN-γ）可诱导非淋巴细胞上主要组织相容性复合体（MHC）II类抗原的表达。在本研究中，我们调查了维生素D3最具活性的代谢产物1,25-二羟维生素D3（1,25(OH)2D3）对γ干扰素诱导人喉表皮样癌细胞（HEp-2细胞）上MHC II类抗原表达的影响。我们发现，1,25(OH)2D3可增强γ干扰素诱导这些细胞上人类白细胞抗原-DR（HLA-DR）的表达。还观察到对MHC II类抗原HLA-DR、-DQ和-DP的不同影响。
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