边缘型人格障碍特征及其与正常人格维度的关系：基于网络的队列和双胞胎研究。
Borderline personality disorder traits and their relationship with dimensions of normative personality: a web-based cohort and twin study.
机构信息
Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Acta Psychiatr Scand. 2011 May;123(5):349-59. doi: 10.1111/j.1600-0447.2010.01653.x. Epub 2010 Dec 28.
OBJECTIVE
To describe the structure of genetic and environmental risk factors for four dimensions of borderline personality disorder (BPD) and to understand the source of resemblance of these dimensions and normal personality.
METHOD
A web-based sample (n = 44,112 including 542 twin pairs) completed items from 4 scales of the Dimensional Assessment of Personality Pathology Basic Questionnaire and the Big Five Inventory.
RESULTS
A one-factor common pathway model best fits the 4 BPD scales producing a highly heritable latent liability (heritability = 60%) and strong loadings on all 4 dimensions. Affective instability had the lowest trait-specific genetic loading, suggesting that it was a core feature of BPD. A complex pattern of genetic and environmental associations was found between the big five personality traits and BPD dimensions. The strongest genetic correlations with the BPD traits were generally seen for neuroticism (positive), followed by conscientiousness and agreeableness, both negative.
CONCLUSION
In the general population, these four BPD dimensions reflect one underlying highly heritable factor. The association between normative personality and dimensions of BPD is complex with high degrees of genetic correlation.
目的
描述边缘型人格障碍（BPD）四个维度的遗传和环境风险因素结构，并了解这些维度与正常人格的相似性来源。
方法
一个基于网络的样本（n=44112，包括542 对双胞胎）完成了人格病理多维评定问卷 4 个量表和大五人格量表的项目。
结果
一个单因素共同途径模型最适合 4 个 BPD 量表，产生了高度可遗传的潜在倾向（遗传度=60%），并且对所有 4 个维度都有很强的负荷。情感不稳定具有最低的特质特异性遗传负荷，这表明它是 BPD 的一个核心特征。在大五人格特质和 BPD 维度之间发现了一种复杂的遗传和环境关联模式。与 BPD 特征最密切的遗传相关性通常见于神经质（正相关），其次是尽责性和宜人性，均为负相关。
结论
在一般人群中，这四个 BPD 维度反映了一个潜在的高度可遗传因素。正常人格与 BPD 维度之间的关联是复杂的，具有高度的遗传相关性。
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