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儿童窄谱中波紫外线光疗:新西兰的经验

Narrowband UVB phototherapy in children: A New Zealand experience.

作者信息

Tan Eugene, Lim David, Rademaker Marius

机构信息

Department of Dermatology, Waikato Hospital, Hamilton, New Zealand.

出版信息

Australas J Dermatol. 2010 Nov;51(4):268-73. doi: 10.1111/j.1440-0960.2010.00701.x. Epub 2010 Oct 13.

Abstract

BACKGROUND

Phototherapy is effective for many dermatoses in adults, but there is a paucity of data for its use in children.

OBJECTIVES

To review the efficacy and tolerability of narrowband UVB phototherapy in children at a tertiary centre in New Zealand, and determine if there were any factors that differentiated responders from non-responders.

METHODS

A prospective analysis of children (<16 years old) who had undergone phototherapy over a 15-year period.

RESULTS

116 children received phototherapy with a total of 144 courses. Mean age was 11.0 years with the majority being European and having skin phototype II. Atopic dermatitis was the most common indication for treatment followed by psoriasis, pityriasis lichenoides, nodular prurigo, morphea, vitiligo, urticaria pigmentosa and erythropoietic porphyria. Treatment was effective in the majority of children (72%). Most received only one course. For responders, the mean number of treatments was 32.4. The mean dose per treatment to achieve clearance was 886 mJ/cm(2) and the mean maximum treatment dose per treatment was 1328 mJ/cm(2) . All children tolerated treatment well with 36% developing brief, minimally symptomatic, erythema. Only two children experienced exacerbations of their underlying dermatoses.

CONCLUSIONS

This study shows that phototherapy is an effective and well-tolerated treatment modality in children.

摘要

背景

光疗对成人的多种皮肤病有效,但用于儿童的相关数据较少。

目的

回顾新西兰一家三级医疗中心窄谱中波紫外线光疗在儿童中的疗效和耐受性,并确定是否存在区分反应者与无反应者的因素。

方法

对15年间接受光疗的16岁以下儿童进行前瞻性分析。

结果

116名儿童接受了光疗,共144个疗程。平均年龄为11.0岁,大多数为欧洲人,皮肤光类型为II型。特应性皮炎是最常见的治疗适应证,其次是银屑病、苔藓样糠疹、结节性痒疹、硬斑病、白癜风、色素性荨麻疹和红细胞生成性卟啉病。大多数儿童(72%)治疗有效。大多数儿童仅接受一个疗程。对于反应者,平均治疗次数为32.4次。达到清除所需的每次治疗平均剂量为886 mJ/cm²,每次治疗的平均最大治疗剂量为1328 mJ/cm²。所有儿童对治疗耐受性良好,36%出现短暂的、症状轻微的红斑。仅有两名儿童出现基础皮肤病加重。

结论

本研究表明,光疗在儿童中是一种有效且耐受性良好的治疗方式。

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