MMP-9、VEGF 和 vWF 在颌骨中央性和外周性巨细胞瘤中的免疫表达。
Immunoexpression of MMP-9, VEGF, and vWF in central and peripheral giant cell lesions of the jaws.
机构信息
Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
出版信息
J Oral Pathol Med. 2011 Apr;40(4):338-44. doi: 10.1111/j.1600-0714.2010.00993.x. Epub 2010 Dec 28.
BACKGROUND
Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are pathological conditions of the jaws that share the same microscopic features, but differ clinically in terms of their behavior. Our aim was to compare the immunoexpression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in CGCL and PGCL, relating them to the angiogenic index.
METHODS
Twenty CGCL and 20 PGCL were selected for analysis of the immunoexpression of MMP-9 and VEGF in multinucleated giant cells (MGC) and mononucleated cells (MC). Angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody.
RESULTS
The CGCL showed slightly higher expression of MMP-9 than PGCL. In comparison with PGCL, the CGCL showed higher expression of VEGF both in MC (P < 0.05) and in total cells (P < 0.05). PGCL exhibited higher MVC than CGCL (P < 0.05).
CONCLUSIONS
MMP-9 and VEGF might play an important role in the osteoclastogenesis process in CGCL. The higher MVC in PGCL might be related to the reactive nature of these lesions.
背景
中央性颌骨 giant cell 病变（CGCL）和周边性颌骨 giant cell 病变（PGCL）是颌骨的病理状况，具有相同的微观特征，但在行为上存在临床差异。我们的目的是比较血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）在 CGCL 和 PGCL 中的免疫表达，并将其与血管生成指数相关联。
方法
选择 20 例 CGCL 和 20 例 PGCL 分析多核巨细胞（MGC）和单核细胞（MC）中 MMP-9 和 VEGF 的免疫表达。利用抗血管性血友病因子抗体测定微血管计数（MVC）来确定血管生成指数。
结果
CGCL 的 MMP-9 表达略高于 PGCL。与 PGCL 相比，CGCL 在 MC（P<0.05）和总细胞（P<0.05）中的 VEGF 表达更高。PGCL 的 MVC 高于 CGCL（P<0.05）。
结论
MMP-9 和 VEGF 可能在 CGCL 的破骨细胞生成过程中发挥重要作用。PGCL 中较高的 MVC 可能与其病变的反应性有关。
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