Flórez-Moreno Gloria Amparo, Henao-Ruiz Marcela, Santa-Sáenz Diana Marcela, Castañeda-Peláez Diego Andrés, Tobón-Arroyave Sergio Iván
Department of Integrated Basic Studies, Medellín, Colombia.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May;105(5):625-32. doi: 10.1016/j.tripleo.2007.08.032. Epub 2008 Mar 4.
To determine whether cytomorphometric differences of multinucleated giant cells (MGCs) and CD68 reactivity of both MGCs and infiltrating macrophages may be associated with the clinical behavior of central and peripheral giant cell lesions of the jaws.
Paraffin-embedded samples of central giant cell lesions (CGCLs; n = 20) and peripheral giant cell lesions (PGCLs; n = 20) were prepared for cytomorphometric analysis and immunohistochemistry.
The nuclei in CGCLs were more numerous, larger, and more irregular than those in PGCLs. Furthermore, CD68 expression and the ratio of CD68(+) macrophage to MGCs were significantly greater in CGCLs than in PGCLs. Statistical correlations between CD68 expression and the staining-intensity distribution score within the diagnostic groups were significant in CGCLs and not significant in PGCLs.
Although the CGCLs share some histopathologic similarities with PGCLs, differences in both nuclear morphometric parameters of MGC and CD68 immunoreactivity may underlie the distinct clinical behavior.
确定多核巨细胞（MGCs）的细胞形态计量学差异以及MGCs和浸润巨噬细胞的CD68反应性是否可能与颌骨中心性和外周性巨细胞病变的临床行为相关。
制备中央巨细胞病变（CGCLs；n = 20）和外周巨细胞病变（PGCLs；n = 20）的石蜡包埋样本，用于细胞形态计量学分析和免疫组织化学。
CGCLs中的细胞核比PGCLs中的细胞核数量更多、更大且更不规则。此外，CGCLs中CD68表达以及CD68(+)巨噬细胞与MGCs的比例显著高于PGCLs。在诊断组内，CD68表达与染色强度分布评分之间的统计相关性在CGCLs中显著，而在PGCLs中不显著。
尽管CGCLs与PGCLs存在一些组织病理学相似性，但MGC的核形态计量学参数和CD68免疫反应性的差异可能是其不同临床行为的基础。
