血浆置换在韦格纳肉芽肿病中治疗指尖梗死的应用。

Utilisation of plasma exchange in the treatment of digital infarcts in Wegener's granulomatosis.

机构信息

Western Health St Vincent's Health, Melbourne, Victoria, Australia.

出版信息

Int J Rheum Dis. 2010 Oct;13(4):e59-61. doi: 10.1111/j.1756-185X.2010.01541.x.

DOI:10.1111/j.1756-185X.2010.01541.x

PMID:21199455

Abstract

Digital ischemia is a rare manifestation of Wegener's granulomatosis (WG) with previous management approaches based on the hypotheses of thromboembolic phenomenon and vasospasm. WG is an autoimmune, antineutrophil cytoplasmic antibody-predominant small-to-medium-vessel necrotising vasculitis which mainly affects the pulmonary-renal system. We report on a patient with WG presenting with digital infarction. We successfully treated this patient who had digital infarcts refractory to cyclophosphamide, steroids and vasodilator agents, with plasma exchange.

摘要

数字缺血是 Wegener 肉芽肿病（WG）的一种罕见表现，既往的治疗方法基于血栓栓塞现象和血管痉挛的假说。WG 是一种自身免疫性、抗中性粒细胞胞质抗体为主的中小血管坏死性血管炎，主要影响肺肾系统。我们报告了一例 WG 患者出现指端梗死。我们成功地用血浆置换治疗了这位患者，他的指端梗死对环磷酰胺、类固醇和血管扩张剂治疗无反应。