Spitzer D, Staudach A, Riedl B, Traun H, Steiner H
Landesfrauenklinik Salzburg.
Geburtshilfe Frauenheilkd. 1990 Aug;50(8):644-6. doi: 10.1055/s-2008-1026517.
More than 95 per cent of the pregnancies with circulating lupus anticoagulant (LA) without therapy lead to abortion or intrauterine death. We report on the course of a pregnancy in a patient, who developed deep venous thrombosis and circulating LA. One of the rare cases of successful pregnancy management without the common prednisolone-aspirin therapy, but with heparin-monotherapy associated with intensive medical and obstetrical surveillance under clinical conditions is reported. In spite of intermittent corticosteroid and immunoglobulin application, a healthy child was born, although normalisation of the aPTT and platelet count was not achieved. It seems, that an alternative concept of therapy may have been established.
超过95%未经治疗的循环狼疮抗凝物（LA）孕妇会发生流产或宫内死亡。我们报告了1例发生深静脉血栓形成和循环LA的孕妇的病程。本文报道了1例罕见病例，该孕妇未采用常规的泼尼松龙 - 阿司匹林治疗，而是在临床条件下采用肝素单一疗法并联合强化内科及产科监测，成功实现了妊娠管理。尽管间歇性应用了皮质类固醇和免疫球蛋白，但仍产下了一名健康婴儿，尽管活化部分凝血活酶时间（aPTT）和血小板计数未恢复正常。似乎已经确立了一种替代治疗方案。
