Williams P E
Department of Medicine, UAMS, Little Rock.
J Ark Med Soc. 1990 May;86(12):493-7.
Lupus anticoagulants have been recognized as significant causes of morbidity in patients for many years. They were originally regarded by physicians and researchers as a nuisance. However, the name is a misnomer that has resisted change over the years. The riddle of the anticoagulant effect in vitro and the apparent procoagulant effect in vivo remains unsolved. Since a lupus anticoagulant can exist in virtually every patient population, it is no longer a topic of interest limited only to the hematologists, but has achieved multidisciplinary attention. The presence of a lupus anticoagulant should be evaluated in any patient who presents with new onset transient ischemic attack or cerebral vascular accident, unexplained deep venous thrombosis, or recurrent fetal wastage.
多年来，狼疮抗凝物一直被认为是患者发病的重要原因。医生和研究人员最初将其视为一种麻烦。然而，这个名称是一个多年来一直未改变的误称。体外抗凝作用和体内明显的促凝作用之谜仍未解开。由于狼疮抗凝物几乎可以存在于每一个患者群体中，它不再只是血液学家感兴趣的话题，而是受到了多学科的关注。对于任何出现新发短暂性脑缺血发作或脑血管意外、不明原因的深静脉血栓形成或反复胎儿流产的患者，都应评估是否存在狼疮抗凝物。
