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7β-羟基青蒿素

7β-Hydroxy-artemisinin.

作者信息

Carvalho Paulo B, Liu Bo, Wu Yunshan, Williamson John S, Avery Mitchell A

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 9;64(Pt 2):o395-6. doi: 10.1107/S1600536808000251.

DOI:10.1107/S1600536808000251
PMID:21201424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2960444/
Abstract

CRYSTALS OF THE TITLE COMPOUND [SYSTEMATIC NAME: (3R,6R,7S,8aR,9R,12aR)-7-hydr-oxy-3,6,9-trimethyl-octa-hydro-3,12-ep-oxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C(15)H(22)O(6), were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. The stereochemistry of the compound is consistent with the spectroscopic findings in previously published works. A weak O-H⋯O hydrogen bond occurs in the crystal structure, together with intermolecular C-H⋯O hydrogen bonds.

摘要

标题化合物[系统名称：(3R,6R,7S,8aR,9R,12aR)-7-羟基-3,6,9-三甲基-八氢-3,12-环氧[1,2]二氧杂环庚并[4,3-i]异苯并呋喃-10(3H)-酮]，化学式为C(15)H(22)O(6)，是通过雅致小克银汉霉菌培养物对青蒿素进行微生物转化得到的。该化合物的立体化学与先前发表的作品中的光谱学研究结果一致。晶体结构中存在一个弱的O-H⋯O氢键以及分子间的C-H⋯O氢键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3a/2960444/9c5f75fc835b/e-64-0o395-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3a/2960444/ef517a4e2833/e-64-0o395-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3a/2960444/9c5f75fc835b/e-64-0o395-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3a/2960444/ef517a4e2833/e-64-0o395-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3a/2960444/9c5f75fc835b/e-64-0o395-fig2.jpg

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