自噬晚期：细胞事件和分子调控。
The late stage of autophagy: cellular events and molecular regulation.
机构信息
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Science, Tsinghua University, Beijing 100084, China.
出版信息
Protein Cell. 2010 Oct;1(10):907-15. doi: 10.1007/s13238-010-0121-z. Epub 2010 Nov 9.
Abstract
Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a "self-eating" process and plays a "house-cleaner" role in cells. The complex process consists of several sequential steps-induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.
摘要
自噬是一种将细胞质内容物输送到溶酶体进行降解的细胞内降解系统。它是一种“自我吞噬”的过程，在细胞中起着“清道夫”的作用。这个复杂的过程包括几个连续的步骤——诱导、自噬体形成、溶酶体与自噬体融合、降解、降解产物的外排转运以及自噬溶酶体的再形成。在这篇综述中，总结了自噬晚期（包括融合步骤后的细胞事件）的细胞和分子调控。
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