Silva Valdenizia R, Neves Sara P, Santos Luciano de S, Dias Rosane B, Bezerra Daniel P
Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
Cancers (Basel). 2020 Nov 20;12(11):3461. doi: 10.3390/cancers12113461.
Autophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells-while in some situations, it has a cytoprotective effect that causes chemotherapy resistance, in others, it has a cytotoxic effect in which some compounds induce autophagy-mediated cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer, including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer stem cells has also been discussed.
自噬是一种生理细胞过程，对发育至关重要，可在营养剥夺或代谢紊乱时发生。有趣的是，自噬在癌细胞中发挥双重作用——在某些情况下，它具有细胞保护作用，导致化疗耐药；而在其他情况下，它具有细胞毒性作用，某些化合物可诱导自噬介导的细胞死亡。在本综述中，我们总结了针对自噬治疗癌症的策略，包括对可调节自噬介导的耐药性的药物，和/或导致自噬介导的癌细胞死亡的药物的研究。此外，还讨论了自噬在癌症干细胞生物学中的作用。
