Levy R A, Gharavi A E, Sammaritano L R, Habina L, Qamar T, Lockshin M D
Hospital for Special Surgery, Cornell University Medical College, New York, NY.
J Rheumatol. 1990 Aug;17(8):1036-41.
To evaluate the similarities and differences of antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE) and syphilis, we studied 20 SLE and 16 syphilis high titer IgG aPL sera for antibody isotype, avidity, phospholipid specificity, light chain and IgG subclass. Syphilis aPL had lower avidity, with kappa light chain and IgG1 and IgG3 predominance, in contrast to higher avidity, with lambda light chain and IgG2 and IgG4 predominance in SLE aPL. Phospholipid specificities were similar. SLE and syphilis aPL both recognize phospholipid epitopes but differ in important antibody characteristics.
为评估系统性红斑狼疮（SLE）和梅毒中抗磷脂抗体（aPL）的异同，我们研究了20份SLE和16份梅毒高滴度IgG aPL血清的抗体同种型、亲和力、磷脂特异性、轻链和IgG亚类。梅毒aPL的亲和力较低，以κ轻链以及IgG1和IgG3为主，而SLE aPL的亲和力较高，以λ轻链以及IgG2和IgG4为主。磷脂特异性相似。SLE和梅毒aPL均识别磷脂表位，但在重要的抗体特征方面存在差异。
