Honda Masaki J, Imaizumi Mari, Tsuchiya Shuhei, Morsczeck Christian
Department of Anatomy, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan.
J Oral Sci. 2010 Dec;52(4):541-52. doi: 10.2334/josnusd.52.541.
Adult stem cells are multipotent and can be induced experimentally to differentiate into various cell lineages. Such cells are therefore a key part of achieving the promise of tissue regeneration. The most studied stem cells are those of the hematopoietic and mesenchymal lineages. Recently, mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, and dental follicle. The dental follicle is a loose connective tissue that surrounds the developing tooth. Dental follicle stem cells could therefore be a cell source for mesenchymal stem cells. Indeed, dental follicle is present in impacted teeth, which are commonly extracted and disposed of as medical waste in dental practice. Dental follicle stem cells can be isolated and grown under defined tissue culture conditions, and recent characterization of these stem cells has increased their potential for use in tissue engineering applications, including periodontal and bone regeneration. This review describes current knowledge and recent developments in dental follicle stem cells and their application.
成体干细胞具有多能性，可通过实验诱导分化为各种细胞谱系。因此，这类细胞是实现组织再生前景的关键部分。研究最多的干细胞是造血谱系和间充质谱系的干细胞。最近，在包括牙髓、牙周韧带和牙囊在内的牙齿组织中发现了间充质干细胞。牙囊是围绕发育中牙齿的疏松结缔组织。因此，牙囊干细胞可能是间充质干细胞的一个细胞来源。事实上，牙囊存在于阻生牙中，在牙科实践中，阻生牙通常作为医疗废物被拔除和丢弃。牙囊干细胞可以在特定的组织培养条件下分离和培养，最近对这些干细胞的特性研究增加了它们在组织工程应用中的潜力，包括牙周和骨再生。这篇综述描述了牙囊干细胞的现有知识和最新进展及其应用。
