Sedgley Christine M, Botero Tatiana M
Department of Endodontology, School of Dentistry, Oregon Health and Science University, 611 Southwest Campus Drive, Portland, OR 97239, USA.
Dent Clin North Am. 2012 Jul;56(3):549-61. doi: 10.1016/j.cden.2012.05.004. Epub 2012 Jun 23.
The search for more accessible mesenchymal stem cells than those found in bone marrow has propelled interest in dental tissues. Human dental stem/progenitor cells (collectively termed dental stem cells [DSCs]) that have been isolated and characterized include dental pulp stem cells, stem cells from exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, and dental follicle progenitor cells. Common characteristics of these cell populations are the capacity for self-renewal and the ability to differentiate into multiple lineages. In vitro and animal studies have shown that DSCs can differentiate into osseous, odontogenic, adipose, endothelial, and neural-like tissues.
寻找比骨髓中更容易获取的间充质干细胞，这推动了人们对牙齿组织的关注。已被分离和鉴定的人类牙齿干/祖细胞（统称为牙齿干细胞[DSCs]）包括牙髓干细胞、脱落乳牙干细胞、根尖乳头干细胞、牙周膜干细胞和牙囊祖细胞。这些细胞群体的共同特征是具有自我更新能力以及分化为多种谱系的能力。体外和动物研究表明，牙齿干细胞可以分化为骨、牙源性、脂肪、内皮和神经样组织。
