Department of Pharmacology, B. J. Medical College, Ahmedabad, India.
Indian J Pharmacol. 2010 Oct;42(5):324-5. doi: 10.4103/0253-7613.70400.
Drugs account for 1-2% of all cases of pancreatitis. A 58-year-old man was prescribed atorvastatin 10 mg for 6 months for hyperlipidemia. He developed acute abdominal pain and vomiting with epigastric tenderness. Serum lipase and CT scan of the patient suggested the presence of acute pancreatitis. The patient was hospitalized; atorvastatin was stopped and treated symptomatically. He recovered completely within 10 days of drug withdrawal. The causality of the adverse drug reaction according to Naranjo and WHO-UMC Scale was probable. The exact mechanism of pancreatitis due to atorvastatin is not known. It may be a class effect of HMG CoA reductase inhibitors as it had been reported with other statins too. The definite causal relationship is difficult to establish, as rechallenge with the suspected drug was not done due to ethical consideration.
药物约占胰腺炎病例的 1-2%。一名 58 岁男性因高血脂症服用阿托伐他汀 10mg 治疗 6 个月。他出现急性腹痛和呕吐，伴有上腹部压痛。患者的血清脂肪酶和 CT 扫描提示存在急性胰腺炎。他住院治疗，停用阿托伐他汀并进行对症治疗。停药 10 天后，他完全康复。根据 Naranjo 和 WHO-UMC 量表，药物不良反应的因果关系为很可能。阿托伐他汀引起胰腺炎的确切机制尚不清楚。它可能是 HMG CoA 还原酶抑制剂的类效应，因为其他他汀类药物也有报道。由于伦理考虑，未能进行可疑药物的再激发试验，因此很难确定明确的因果关系。
