Taksande Amar, Vilhekar Krishna, Chaturvedi Pushpa, Jain Manish
Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra - 442 102, India.
Indian J Hum Genet. 2010 Sep;16(3):159-63. doi: 10.4103/0971-6866.73412.
To study the incidence of congenital anomalies and the associated risk factors in Department of Pediatrics at Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, a rural medical college hospital in central Maharashtra.
All the intramural deliveries between 1 January 2005 and 31 July 2007 comprised 9386 births and their 9324 mothers (62 mothers gave birth to twin babies). The newborns were examined and assessed systematically for the presence of congenital anomalies, system wise distribution of anomalies and risk factors attributable.
Out of the total 9386 deliveries, 9194 were live births and 192 were stillbirths. The total number of babies with congenital malformations was 179 (1.91%). Out of the 9262 singleton births, 177 (1.05%) were malformed, whereas 2 of the 62 pairs of twins had birth defects. Nine of the 179 malformed babies (5.02%) were still born. Prematurity, increased maternal age, increasing birth order and low birth weight were found to have a higher risk of congenital anomalies. Cardiovascular malformations were most common in live births, followed by musculoskeletal and genitourinary anomalies.
Congenital anomalies are a major cause of stillbirths and infant mortality. Evaluation of cardiovascular system to rule out congenital heart disease in high-risk mothers' babies is the important factor to be considered.
研究位于马哈拉施特拉邦中部农村地区的医学院校医院——塞瓦格拉姆圣雄甘地医学科学研究所儿科先天性异常的发病率及其相关危险因素。
2005年1月1日至2007年7月31日期间所有住院分娩的9386例新生儿及其9324名母亲(62名母亲产下双胞胎)。对新生儿进行系统检查和评估,以确定是否存在先天性异常、异常的系统分布以及可归因的危险因素。
在9386例分娩中,9194例为活产,192例为死产。先天性畸形婴儿总数为179例(1.91%)。在9262例单胎分娩中,177例(1.05%)有畸形,而62对双胞胎中有2例有出生缺陷。179例畸形婴儿中有9例(5.02%)为死产。早产、母亲年龄增加、产次增加和低出生体重被发现有较高的先天性异常风险。心血管畸形在活产中最为常见,其次是肌肉骨骼和泌尿生殖系统异常。
先天性异常是死产和婴儿死亡的主要原因。对高危母亲的婴儿进行心血管系统评估以排除先天性心脏病是需要考虑的重要因素。