Siddika M, Sen S, Islam M N, Bhuiyan M K
Dr Mohosina Siddika, Associate Professor, Department of Gyeanocology & Obstetrics, Community Based Medical Colloge Bangladesh, Mymensingh, Bangladesh.
Mymensingh Med J. 2018 Oct;27(4):805-812.
The cross sectional study was done to estimate the prevalence of various congenital malformations among the patients delivered in Community Based Medical College Hospital (CBMCH), Mymensingh, Bangladesh and corresponding risk factors were also studied from July 2014 to December 2015. A total of 2560 babies who were born at Community Based Medical College Hospital (CBMCH) were enrolled in this study. The newborn babies were examined and assessed for detection of congenital malformation, system wise distribution and risk factors attributable. Out of total 2560 deliveries, 2548 were live births and 12 were still birth. The total number of babies with congenital malformation was 52(2.03%). Four of the 52(7.69%) malformed babies were still born. Maternal age; like increased or low maternal age, maternal disease and drugs were found to have a higher risk of congenital anomalies. Alimentary system and head neck malformation (25%) were most common. All of the still birth babies were born with central nervous system (CNS) malformation. Central nervous system (21.2%), Cardiovascular (17.3%), Musculoskeletal (13.5%), Genitourinary (11.5%), Chromosomal (5.8%) and other (5.8%) abnormalities fall in descending order of frequency. Congenital anomalies are one of the major causes to infant mortality. The study shows the prevalence of congenital anomalies 20.3/1000 live birth and most commonly involved body systems were alimentary system and head neck trunk 13(25%). A good number of mothers have got some definite diseases like diabetes mellitus, infections and hypertension. Consanguinity of marriage and exposure to some drugs has some correlation with congenital malformation. Early diagnosis of diseases and proper counseling with the parents will help in early intervention and reduce mortality and morbidity of neonates.
为了估计孟加拉国迈门辛社区医学院医院(CBMCH)分娩患者中各种先天性畸形的患病率,并研究相应的风险因素,于2014年7月至2015年12月进行了这项横断面研究。共有2560名在社区医学院医院(CBMCH)出生的婴儿纳入本研究。对新生儿进行检查和评估,以检测先天性畸形、系统分布及相关风险因素。在总共2560例分娩中,2548例为活产,12例为死产。先天性畸形婴儿总数为52例(2.03%)。52例畸形婴儿中有4例(7.69%)为死产。发现母亲年龄,如母亲年龄增加或降低、母亲疾病和药物使用与先天性异常风险较高有关。消化系统和头颈部畸形(25%)最为常见。所有死产婴儿均患有中枢神经系统(CNS)畸形。中枢神经系统(21.2%)、心血管系统(17.3%)、肌肉骨骼系统(13.5%)、泌尿生殖系统(11.5%)、染色体(5.8%)和其他(5.8%)异常按频率从高到低排列。先天性异常是婴儿死亡的主要原因之一。该研究显示先天性异常的患病率为20.3/1000活产,最常涉及的身体系统是消化系统和头颈部躯干,共13例(25%)。许多母亲患有某些明确的疾病,如糖尿病、感染和高血压。近亲结婚和接触某些药物与先天性畸形有一定关联。疾病的早期诊断和对父母的适当咨询将有助于早期干预,降低新生儿的死亡率和发病率。