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印度东部一家三级护理医院新生儿先天性异常的患病率及相关危险因素

Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India.

作者信息

Sarkar Shatanik, Patra Chaitali, Dasgupta Malay Kumar, Nayek Kaustav, Karmakar Prasanta Ray

机构信息

Department of Pediatric Medicine, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India.

出版信息

J Clin Neonatol. 2013 Jul;2(3):131-4. doi: 10.4103/2249-4847.119998.

Abstract

BACKGROUND

Congenital anomalies are a major cause of stillbirths and neonatal mortality. The pattern and prevalence of congenital anomalies may vary over time or with geographical location.

AIMS AND OBJECTIVES

The aim of this study is to determine the proportion and types of congenital anomalies in live newborns and to study maternal and perinatal risk factors.

MATERIALS AND METHODS

This cross-sectional descriptive study was carried out in the neonatal care unit of R. G. Kar Medical College and Hospital during the period of September 2011 to August 2012. All the live born babies born in this hospital during this period were included. The newborns were examined for the presence of congenital anomalies and mothers were interviewed for socio-demographic variables.

RESULTS

During the study period, 12,896 babies were born, of which 286 had congenital malformations, making the prevalence 2.22%. Most of the women (55.7%) belonged to the age group between 21 and 30 years. Congenital anomalies were seen more commonly (3.3%) in the multiparas in comparison with primiparas (1.8%). The predominant system involved was Musculo-skeletal system (33.2%) followed by gastro-intestinal (GI) system (15%). Talipes (17.1%) was the most common one in musculoskeletal group and likewise cleft lip and cleft palate in GI system. Congenital anomalies were more likely to be associated with low birth weight, prematurity, multiparity, consanguinity and cesarean delivery.

CONCLUSION

Public awareness about preventable risk factors is to be created and early prenatal diagnosis and management of common anomalies is strongly recommended.

摘要

背景

先天性异常是死产和新生儿死亡的主要原因。先天性异常的模式和患病率可能随时间或地理位置而变化。

目的

本研究的目的是确定活产新生儿中先天性异常的比例和类型,并研究母亲和围产期危险因素。

材料与方法

本横断面描述性研究于2011年9月至2012年8月在R.G.卡尔医学院和医院的新生儿护理病房进行。纳入在此期间在该医院出生的所有活产婴儿。对新生儿进行先天性异常检查,并对母亲进行社会人口统计学变量访谈。

结果

在研究期间,共出生12,896名婴儿,其中286名有先天性畸形,患病率为2.22%。大多数女性(55.7%)年龄在21至30岁之间。与初产妇(1.8%)相比,经产妇中先天性异常更为常见(3.3%)。受累最主要的系统是肌肉骨骼系统(33.2%),其次是胃肠道(GI)系统(15%)。马蹄足(17.1%)是肌肉骨骼组中最常见的畸形,同样唇腭裂是胃肠道系统中最常见的畸形。先天性异常更可能与低出生体重、早产、多产、近亲结婚和剖宫产有关。

结论

应提高公众对可预防危险因素的认识,并强烈建议对常见异常进行早期产前诊断和管理。

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