Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, 2400, Copenhagen, Denmark.
J Neural Transm (Vienna). 2011 Apr;118(4):621-7. doi: 10.1007/s00702-010-0566-5. Epub 2011 Jan 5.
There is an increased but variable risk of epilepsy in autism spectrum disorders. The objective of this study is to compare the prevalence and types of epilepsy and other central nervous system (CNS) diseases in a clinical sample of 89 individuals diagnosed as children with atypical autism (AA) with 258 matched controls from the general population. Diagnoses were based on data from the nationwide Danish National Hospital Register. The average observation time was 32.9 years, and mean age at follow-up was 48.5 years. Of the 89 individuals with AA, 20 (22.5%) were registered with at least one epilepsy diagnosis against 11 (4.3%) in the comparison group (P < 0.0001; OR 6.5; 95% CI 3.0-14.2). Other CNS diseases occurred with low frequency in both groups, and no single CNS disease (except epilepsy) was significantly more frequent among patients with AA. Low intelligence was a risk factor for epilepsy in AA.
自闭症谱系障碍患者癫痫的风险增加，但具有变异性。本研究的目的是比较在临床样本中诊断为非典型自闭症（AA）的 89 名个体和来自普通人群的 258 名匹配对照者中癫痫和其他中枢神经系统（CNS）疾病的患病率和类型。诊断基于全国丹麦国家医院登记处的数据。平均观察时间为 32.9 年，随访时的平均年龄为 48.5 岁。在 89 名患有 AA 的个体中，有 20 名（22.5%）至少有一次癫痫诊断，而对照组为 11 名（4.3%）（P < 0.0001；OR 6.5；95% CI 3.0-14.2）。两组中其他 CNS 疾病的发生率均较低，并且除癫痫外，没有任何单一的 CNS 疾病在 AA 患者中更为常见。智力低下是 AA 患者癫痫的危险因素。
