Mouridsen Svend Erik, Hauschild Karen-Marie
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark.
Logoped Phoniatr Vocol. 2011 Dec;36(4):145-9. doi: 10.3109/14015439.2011.566575. Epub 2011 Mar 29.
Little is known about the familial characteristics of children diagnosed during childhood as having a developmental language disorder (DLD). This study aimed to investigate the prevalence of autism spectrum disorders (ASD) in siblings of probands diagnosed during childhood as having a DLD. In order to estimate the prevalence of ASD, 908 siblings of 469 probands diagnosed during childhood as having a DLD, and 3,802 siblings of 2,345 controls from the general population, without a known history of DLD, were screened for ASD through the nationwide Danish Psychiatric Central Register (DPCR). The mean length of observation was 35.2 years and 34.8 years, respectively, and the mean age at follow-up 38.4 years and 37.4 years, respectively. At follow-up one sibling (0.1%) in the DLD case group and eight siblings (0.2%) in the comparison group were known in the DPCR with a diagnosis of any ASD (P = 0.53; OR = 0.52; 95%CI 0.07-4.19). Thus our results provide no support for a familial association between DLD and ASD.
对于童年时期被诊断为患有发育性语言障碍（DLD）的儿童的家族特征，人们了解甚少。本研究旨在调查童年时期被诊断为患有DLD的先证者的兄弟姐妹中自闭症谱系障碍（ASD）的患病率。为了估计ASD的患病率，通过丹麦全国精神病学中央登记处（DPCR）对469名童年时期被诊断为患有DLD的先证者的908名兄弟姐妹，以及来自普通人群、无已知DLD病史的2345名对照的3802名兄弟姐妹进行了ASD筛查。观察的平均时长分别为35.2年和34.8年，随访时的平均年龄分别为38.4岁和37.4岁。随访时，DLD病例组中有一名兄弟姐妹（0.1%），对照组中有八名兄弟姐妹（0.2%）在DPCR中被诊断为患有任何ASD（P = 0.53；OR = 0.52；95%CI 0.07 - 4.19）。因此，我们的结果不支持DLD与ASD之间存在家族关联。
