细胞器中的腺嘌呤核苷酸转运蛋白：新基因和新功能。
Adenine nucleotide transporters in organelles: novel genes and functions.
机构信息
Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa UAM-CSIC, CIBER de Enfermedades Raras, Universidad Autónoma de Madrid, Madrid, Spain.
出版信息
Cell Mol Life Sci. 2011 Apr;68(7):1183-206. doi: 10.1007/s00018-010-0612-3. Epub 2011 Jan 5.
Abstract
In eukaryotes, cellular energy in the form of ATP is produced in the cytosol via glycolysis or in the mitochondria via oxidative phosphorylation and, in photosynthetic organisms, in the chloroplast via photophosphorylation. Transport of adenine nucleotides among cell compartments is essential and is performed mainly by members of the mitochondrial carrier family, among which the ADP/ATP carriers are the best known. This work reviews the carriers that transport adenine nucleotides into the organelles of eukaryotic cells together with their possible functions. We focus on novel mechanisms of adenine nucleotide transport, including mitochondrial carriers found in organelles such as peroxisomes, plastids, or endoplasmic reticulum and also mitochondrial carriers found in the mitochondrial remnants of many eukaryotic parasites of interest. The extensive repertoire of adenine nucleotide carriers highlights an amazing variety of new possible functions of adenine nucleotide transport across eukaryotic organelles.
摘要
在真核生物中，细胞能量以 ATP 的形式通过糖酵解在线粒体中产生，或者通过氧化磷酸化在真核生物中产生，在光合生物中通过光合磷酸化产生。腺嘌呤核苷酸在细胞区室之间的运输是必不可少的，主要由线粒体载体家族的成员完成，其中最著名的是 ADP/ATP 载体。这项工作综述了将腺嘌呤核苷酸转运到真核细胞细胞器的载体及其可能的功能。我们专注于腺嘌呤核苷酸转运的新机制，包括在过氧化物酶体、质体或内质网等细胞器中发现的线粒体载体，以及在许多有研究价值的真核寄生虫线粒体残余物中发现的线粒体载体。腺嘌呤核苷酸载体的广泛组成突出了腺嘌呤核苷酸跨真核细胞器运输的令人惊讶的多种新的可能功能。
相似文献
1
Adenine nucleotide transporters in organelles: novel genes and functions.细胞器中的腺嘌呤核苷酸转运蛋白：新基因和新功能。
Cell Mol Life Sci. 2011 Apr;68(7):1183-206. doi: 10.1007/s00018-010-0612-3. Epub 2011 Jan 5.
2
A novel ADP/ATP transporter in the mitosome of the microaerophilic human parasite Entamoeba histolytica.一种存在于微需氧人体寄生虫溶组织内阿米巴线粒体中的新型ADP/ATP转运蛋白。
Curr Biol. 2005 Apr 26;15(8):737-42. doi: 10.1016/j.cub.2005.02.068.
3
A Single Cysteine Residue in the Translocation Pathway of the Mitosomal ADP/ATP Carrier from Confers a Broad Nucleotide Specificity.单一半胱氨酸残基在介导体 ADP/ATP 载体的移位途径中赋予了广泛的核苷酸特异性。
Int J Mol Sci. 2020 Nov 26;21(23):8971. doi: 10.3390/ijms21238971.
4
The ADP and ATP transport in mitochondria and its carrier.线粒体中的二磷酸腺苷（ADP）和三磷酸腺苷（ATP）转运及其载体
Biochim Biophys Acta. 2008 Oct;1778(10):1978-2021. doi: 10.1016/j.bbamem.2008.04.011. Epub 2008 May 2.
5
A divergent ADP/ATP carrier in the hydrogenosomes of Trichomonas gallinae argues for an independent origin of these organelles.鸡毛滴虫氢化酶体中一种不同的ADP/ATP载体表明这些细胞器有独立的起源。
Mol Microbiol. 2004 Mar;51(5):1439-46. doi: 10.1111/j.1365-2958.2004.03918.x.
6
Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport.酵母Sal1和Aac2载体通过一种不同于腺嘌呤核苷酸转运的活性对线粒体功能产生多效性影响。
Mol Genet Genomics. 2008 Jul;280(1):25-39. doi: 10.1007/s00438-008-0342-5. Epub 2008 Apr 23.
7
The transport mechanism of the mitochondrial ADP/ATP carrier.线粒体ADP/ATP载体的转运机制。
Biochim Biophys Acta. 2016 Oct;1863(10):2379-93. doi: 10.1016/j.bbamcr.2016.03.015. Epub 2016 Mar 19.
8
Direct thyroid hormone signalling via ADP-ribosylation controls mitochondrial nucleotide transport and membrane leakiness by changing the conformation of the adenine nucleotide transporter.通过ADP-核糖基化的直接甲状腺激素信号传导通过改变腺嘌呤核苷酸转运体的构象来控制线粒体核苷酸转运和膜通透性。
FEBS Lett. 1996 Sep 23;394(1):61-5. doi: 10.1016/0014-5793(96)00921-0.
9
Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles.氢化酶体和线粒体ADP/ATP载体的保守特性：两种细胞器的共同起源。
EMBO J. 2002 Feb 15;21(4):572-9. doi: 10.1093/emboj/21.4.572.
10
BCL-2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA.BCL-2可改善氧化磷酸化，并调节携带突变型线粒体DNA的细胞线粒体中的腺嘌呤核苷酸转运。
J Biol Chem. 2003 Feb 21;278(8):5639-45. doi: 10.1074/jbc.M203080200. Epub 2002 Nov 12.
引用本文的文献
1
A comparison of transporter gene expression in three species of Peronospora plant pathogens during host infection.在宿主侵染过程中三种疫霉属植物病原菌中转运蛋白基因表达的比较。
PLoS One. 2023 Jun 1;18(6):e0285685. doi: 10.1371/journal.pone.0285685. eCollection 2023.
2
Learning from Yeast about Mitochondrial Carriers.从酵母中了解线粒体载体。
Microorganisms. 2021 Sep 28;9(10):2044. doi: 10.3390/microorganisms9102044.
3
Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes.不同大鼠脑区的蛋白质组学分析揭示了长期母婴分离对细胞死亡相关过程中涉及的蛋白质的调节作用。
Biol Res. 2021 Feb 8;54(1):4. doi: 10.1186/s40659-021-00327-5.
4
Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.线粒体与细胞核的冲突与合作控制着基因型、表型和环境的整合。
Philos Trans R Soc Lond B Biol Sci. 2020 Jan 20;375(1790):20190188. doi: 10.1098/rstb.2019.0188. Epub 2019 Dec 2.
5
De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise.SLC25A24基因的新生突变导致一种以早衰、骨骼发育异常、特殊面容和早夭为特征的疾病。
Am J Hum Genet. 2017 Nov 2;101(5):844-855. doi: 10.1016/j.ajhg.2017.09.017.
6
The regulation of neuronal mitochondrial metabolism by calcium.钙对神经元线粒体代谢的调节
J Physiol. 2015 Aug 15;593(16):3447-62. doi: 10.1113/JP270254.
7
Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.腺嘌呤核苷酸转位酶 4 在胚胎卵巢中表达，在卵子发生过程中是可有可无的。
Reprod Sci. 2015 Feb;22(2):250-7. doi: 10.1177/1933719114542026. Epub 2014 Jul 16.
8
A self-sequestered calmodulin-like Ca²⁺ sensor of mitochondrial SCaMC carrier and its implication to Ca²⁺-dependent ATP-Mg/P(i) transport.线粒体 SCaMC 载体的自隔离钙调蛋白样 Ca²⁺传感器及其对 Ca²⁺依赖的 ATP-Mg/P(i)转运的影响。
Structure. 2014 Feb 4;22(2):209-17. doi: 10.1016/j.str.2013.10.018. Epub 2013 Dec 12.
9
Physiological and pathological roles of mitochondrial SLC25 carriers.线粒体 SLC25 载体的生理和病理作用。
Biochem J. 2013 Sep 15;454(3):371-86. doi: 10.1042/BJ20121753.
10
Function and evolution of channels and transporters in photosynthetic membranes.光合作用膜中通道和转运蛋白的功能与进化。
Cell Mol Life Sci. 2014 Mar;71(6):979-98. doi: 10.1007/s00018-013-1412-3. Epub 2013 Jul 9.
本文引用的文献
1
Mitochondrial metabolite transport.线粒体代谢物转运。
Essays Biochem. 2010;47:37-52. doi: 10.1042/bse0470037.
2
The first metazoa living in permanently anoxic conditions.首例永久性缺氧环境中生存的后生动物。
BMC Biol. 2010 Apr 6;8:30. doi: 10.1186/1741-7007-8-30.
3
Mitochondrial carriers function as monomers.线粒体载体以单体形式发挥作用。
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):817-31. doi: 10.1016/j.bbabio.2010.03.023. Epub 2010 Mar 31.
4
Role of thylakoid ATP/ADP carrier in photoinhibition and photoprotection of photosystem II in Arabidopsis.类囊体 ATP/ADP 载体在拟南芥光系统 II 光抑制和光保护中的作用。
Plant Physiol. 2010 Jun;153(2):666-77. doi: 10.1104/pp.110.155804. Epub 2010 Mar 31.
5
The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica.溶组织内阿米巴变性线粒体中蛋白输入的要点。
PLoS Pathog. 2010 Mar 19;6(3):e1000812. doi: 10.1371/journal.ppat.1000812.
6
The genome of Naegleria gruberi illuminates early eukaryotic versatility.格氏嗜热四膜虫基因组揭示了早期真核生物的多功能性。
Cell. 2010 Mar 5;140(5):631-42. doi: 10.1016/j.cell.2010.01.032.
7
Adenine nucleotide transport via Sal1 carrier compensates for the essential function of the mitochondrial ADP/ATP carrier.通过 Sal1 载体进行腺嘌呤核苷酸转运可补偿线粒体 ADP/ATP 载体的基本功能。
FEMS Yeast Res. 2010 May;10(3):290-6. doi: 10.1111/j.1567-1364.2010.00606.x. Epub 2010 Jan 8.
8
Diversity and reductive evolution of mitochondria among microbial eukaryotes.微生物真核生物中线粒体的多样性和简约性进化。
Philos Trans R Soc Lond B Biol Sci. 2010 Mar 12;365(1541):713-27. doi: 10.1098/rstb.2009.0224.
9
The hydrogenosomes of Psalteriomonas lanterna.灯眼虫属的氢化体。
BMC Evol Biol. 2009 Dec 9;9:287. doi: 10.1186/1471-2148-9-287.
10
Bacterial-type oxygen detoxification and iron-sulfur cluster assembly in amoebal relict mitochondria.类细菌型氧解毒与铁硫簇组装在变形虫遗留的线粒体中。
Cell Microbiol. 2010 Mar;12(3):331-42. doi: 10.1111/j.1462-5822.2009.01397.x. Epub 2009 Nov 3.
Zotero 插件