Laboratory for Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Physiol Res. 2010;59(6):1029-1032. doi: 10.33549/physiolres.932039.
The gene for connexin 37 (Cx37) is considered to be one of the candidate genes for cardiovascular disease. We evaluated the association between Cx37 (1019C>T) gene polymorphism (Pro319Ser) and ankle brachial blood pressure index (ABI) in women with type 1 (n=178) and type 2 (n=111) diabetes, and in women from general population (n=862). All women were genotyped for Cx37 polymorphism. In addition to traditional cardiovascular risk factors, ABI was analyzed. In women with type 1 diabetes, ABI significantly decreased from TT to CC carriers (p for trend = 0.008). A similar trend was seen in women with type 2 diabetes (p = 0.050) and in women with waist circumference above 75th percentile (94 cm; n=208) of the general population (p = 0.049). The gene for Cx37 was associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in women with advanced central obesity. The presence of C allele indicated increased risk.
连接蛋白 37（Cx37）基因被认为是心血管疾病的候选基因之一。我们评估了 Cx37（1019C>T）基因多态性（Pro319Ser）与 1 型（n=178）和 2 型（n=111）糖尿病女性以及普通人群女性（n=862）的踝臂血压指数（ABI）之间的关联。所有女性均进行了 Cx37 多态性的基因分型。除了传统的心血管危险因素外，还分析了 ABI。在 1 型糖尿病女性中，ABI 从 TT 携带者到 CC 携带者显著降低（趋势 p=0.008）。在 2 型糖尿病女性（p=0.050）和普通人群中腰围超过第 75 百分位数（94 厘米；n=208）的女性中也观察到类似的趋势（p=0.049）。Cx37 基因与 1 型和 2 型糖尿病以及中央肥胖进展女性的亚临床动脉粥样硬化有关。C 等位基因的存在表明风险增加。
