Boggust W A, McGauley H
Br J Cancer. 1978 Aug;38(2):329-34. doi: 10.1038/bjc.1978.206.
Collagen-peptidase activity in extracts of HeLa cells and human tumours is inactivated by Razoxane (ICRF-159), cyclophosphamide, 5-fluorouracil, thiotepa, aprotinin, EDTA and phenanthroline. As this activity, in association with other enzymes, may contribute to tissue lysis in cancers, chemical intervention may reduce invasiveness and modify the processes of infiltration and metastasis. Accordingly, some drugs used in therapy or for the prevention of metastasis may produce their observed effects by a combination of factors including enzyme inhibition.
海拉细胞提取物和人类肿瘤中的胶原肽酶活性可被雷佐生（ICRF - 159）、环磷酰胺、5 - 氟尿嘧啶、噻替派、抑肽酶、乙二胺四乙酸和菲咯啉灭活。由于这种活性与其他酶共同作用可能导致癌症中的组织溶解，化学干预可能会降低侵袭性并改变浸润和转移过程。因此，一些用于治疗或预防转移的药物可能通过包括酶抑制在内的多种因素共同作用产生其观察到的效果。
