原位成纤维细胞在硬癌型胃癌发生中的作用
Role of orthotopic fibroblasts in the development of scirrhous gastric carcinoma.
作者信息
Yashiro M, Chung Y S, Sowa M
机构信息
First Department of Surgery, Osaka City University Medical School.
出版信息
Jpn J Cancer Res. 1994 Sep;85(9):883-6. doi: 10.1111/j.1349-7006.1994.tb02963.x.
Abstract
We examined the interaction between scirrhous gastric cancer cells and organ-specific fibroblasts in vivo and in vitro. Co-inoculation of scirrhous gastric cancer cells with gastric fibroblasts into nude mice specifically increased tumorigenicity, compared with that of gastric cancer cells alone. Furthermore, the histologic findings of the xenograft produced by co-inoculation with gastric fibroblasts was similar to that of human scirrhous gastric carcinoma. Conditioned medium from gastric fibroblasts significantly stimulated the growth of gastric cancer cells. These findings suggest that the growth of scirrhous gastric cancer cells was affected by orthotopic fibroblasts.
摘要
我们在体内和体外研究了硬癌性胃癌细胞与器官特异性成纤维细胞之间的相互作用。与单独接种胃癌细胞相比，将硬癌性胃癌细胞与胃成纤维细胞共同接种到裸鼠体内可特异性增加致瘤性。此外，与胃成纤维细胞共同接种产生的异种移植瘤的组织学表现与人类硬癌性胃癌相似。胃成纤维细胞的条件培养基显著刺激了胃癌细胞的生长。这些发现表明，原位成纤维细胞会影响硬癌性胃癌细胞的生长。
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