秀丽隐杆线虫在神经退行性疾病中金属作用的研究进展。
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
机构信息
Division of Clinical Pharmacology and Pediatric Toxicology, Vanderbilt University Medical Center, 11425 MRB IV, 2215-B Garland Ave., Nashville, TN 37232-0414, USA.
出版信息
Metallomics. 2011 Mar;3(3):271-9. doi: 10.1039/c0mt00064g. Epub 2011 Jan 6.
Abstract
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
摘要
神经退行性变的特征是神经元的死亡或结构和/或功能的丧失。许多神经退行性疾病，包括帕金森病（PD）和阿尔茨海默病（AD），都是神经退行性过程的结果。金属对于许多生命过程是必不可少的，但它们也是几种神经退行性机制的罪魁祸首。在这篇综述中，我们讨论了金属在神经退行性疾病中的作用，重点介绍了秀丽隐杆线虫（C. elegans）遗传模型在破译与 PD 和 AD 病因相关的机制方面的应用。
相似文献
1
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.秀丽隐杆线虫在神经退行性疾病中金属作用的研究进展。
Metallomics. 2011 Mar;3(3):271-9. doi: 10.1039/c0mt00064g. Epub 2011 Jan 6.
2
Copper-mediated neurotoxicity and genetic vulnerability in the background of neurodegenerative diseases in C. elegans.铜介导的神经毒性和神经退行性疾病背景下秀丽隐杆线虫的遗传易感性。
Toxicol Sci. 2024 Oct 1;201(2):254-262. doi: 10.1093/toxsci/kfae092.
3
Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.秀丽隐杆线虫作为研究复杂神经疾病（帕金森病、阿尔茨海默病和自闭症谱系障碍）的实验工具。
Invert Neurosci. 2011 Dec;11(2):73-83. doi: 10.1007/s10158-011-0126-1. Epub 2011 Nov 8.
4
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.延长金属硫蛋白诱导可抵抗老年转基因秀丽隐杆线虫中 Aβ 和 α-突触核蛋白毒性。
Sci Rep. 2020 Jul 16;10(1):11707. doi: 10.1038/s41598-020-68561-7.
5
Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation.利用秀丽隐杆线虫作为神经退行性疾病模型：方法学与评估。
Methods Cell Biol. 2024;188:1-34. doi: 10.1016/bs.mcb.2024.03.004. Epub 2024 Apr 25.
6
C. elegans as a genetic model system to identify Parkinson's disease-associated therapeutic targets.秀丽隐杆线虫作为遗传模式系统，用于鉴定帕金森病相关治疗靶点。
CNS Neurol Disord Drug Targets. 2012 Dec;11(8):957-64. doi: 10.2174/1871527311211080004.
7
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases.秀丽隐杆线虫：一种用于研究年龄相关性神经退行性疾病的转基因模型。
Ageing Res Rev. 2023 Nov;91:102036. doi: 10.1016/j.arr.2023.102036. Epub 2023 Aug 19.
8
Towards Understanding Neurodegenerative Diseases: Insights from .从 中了解神经退行性疾病：见解 。
Int J Mol Sci. 2023 Dec 28;25(1):443. doi: 10.3390/ijms25010443.
9
Regulation of TIR-1/SARM-1 by miR-71 Protects Dopaminergic Neurons in a Model of LRRK2-Induced Parkinson's Disease.miR-71 通过调控 TIR-1/SARM-1 对 LRRK2 诱导的帕金森病模型中多巴胺能神经元起保护作用。
Int J Mol Sci. 2024 Aug 13;25(16):8795. doi: 10.3390/ijms25168795.
10
The nematode Caenorhabditis elegans: a versatile model for the study of proteotoxicity and aging.秀丽隐杆线虫：研究蛋白毒性和衰老的多功能模型。
Methods. 2014 Aug 1;68(3):458-64. doi: 10.1016/j.ymeth.2014.04.014. Epub 2014 Apr 30.
引用本文的文献
1
as a suitable model to evaluate the toxicity of water from Rolante River, southern Brazil.作为评估巴西南部罗兰蒂河河水毒性的合适模型。
Toxicol Res (Camb). 2023 Dec 18;13(1):tfad117. doi: 10.1093/toxres/tfad117. eCollection 2024 Feb.
2
as a Model to Study Manganese-Induced Neurotoxicity.作为研究锰诱导神经毒性的模型。
Biomolecules. 2022 Sep 29;12(10):1396. doi: 10.3390/biom12101396.
3
Iron overload and neurodegenerative diseases: What can we learn from ?铁过载与神经退行性疾病：我们能从中学到什么？
Toxicol Res Appl. 2022 Jan-Dec;6. doi: 10.1177/23978473221091852. Epub 2022 Apr 23.
4
Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in .荧光显微镜和行为分析在展示……中神经元连接组和神经递质系统的应用
Neuromethods. 2021;172:399-426. Epub 2021 Jul 24.
5
Detrimental effects of long-term elevated serum uric acid on cognitive function in rats.长期血尿酸升高对大鼠认知功能的损害作用。
Sci Rep. 2021 Mar 24;11(1):6732. doi: 10.1038/s41598-021-86279-y.
6
and Neurodegeneration .以及神经退行性变
Adv Med Biol. 2012;44:1-46.
7
-An Emerging Model to Study Metal-Induced RAGE-Related Pathologies.一种研究金属诱导的 RAGE 相关病理学的新兴模型。
Int J Environ Res Public Health. 2018 Jul 4;15(7):1407. doi: 10.3390/ijerph15071407.
8
An enhanced C. elegans based platform for toxicity assessment.基于秀丽隐杆线虫的毒性评估增强平台。
Sci Rep. 2017 Aug 29;7(1):9839. doi: 10.1038/s41598-017-10454-3.
9
Copper Oxide Nanoparticles Impact Several Toxicological Endpoints and Cause Neurodegeneration in Caenorhabditis elegans.氧化铜纳米颗粒影响多个毒理学终点并导致秀丽隐杆线虫神经退行性变。
PLoS One. 2016 Dec 2;11(12):e0167613. doi: 10.1371/journal.pone.0167613. eCollection 2016.
10
Neurochemistry of lead and manganese.铅与锰的神经化学
Metallomics. 2016 Jun 1;8(6):561-2. doi: 10.1039/c6mt90017h.
本文引用的文献
1
Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans.细胞外多巴胺以 BLI-3 依赖的方式增强 mn 诱导的氧化应激、寿命缩短和多巴胺能神经元退行性变在秀丽隐杆线虫中。
PLoS Genet. 2010 Aug 26;6(8):e1001084. doi: 10.1371/journal.pgen.1001084.
2
SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity.SKN-1/Nrf2 抑制甲基汞毒性线虫模型中多巴胺神经元的变性。
Toxicol Sci. 2010 Dec;118(2):613-24. doi: 10.1093/toxsci/kfq285. Epub 2010 Sep 20.
3
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.α-突触核蛋白抑制线粒体融合可被 PINK1、Parkin 和 DJ-1 挽救。
EMBO J. 2010 Oct 20;29(20):3571-89. doi: 10.1038/emboj.2010.223. Epub 2010 Sep 14.
4
Alzheimer disease.阿尔茨海默病
Dis Mon. 2010 Sep;56(9):484-546. doi: 10.1016/j.disamonth.2010.06.001.
5
Gene-environment interactions in Parkinson's disease: the importance of animal modeling.帕金森病中的基因-环境相互作用：动物模型的重要性。
Clin Pharmacol Ther. 2010 Oct;88(4):467-74. doi: 10.1038/clpt.2010.138. Epub 2010 Sep 1.
6
Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms.环境暴露、肥胖与帕金森病：从胖老线虫中得到的启示。
Environ Health Perspect. 2011 Jan;119(1):20-8. doi: 10.1289/ehp.1002522. Epub 2010 Aug 25.
7
Metals, oxidative stress and neurodegenerative disorders.金属、氧化应激与神经退行性疾病。
Mol Cell Biochem. 2010 Dec;345(1-2):91-104. doi: 10.1007/s11010-010-0563-x. Epub 2010 Aug 22.
8
Hormetic effect of methylmercury on Caenorhabditis elegans.甲基汞对秀丽隐杆线虫的适应效应。
Toxicol Appl Pharmacol. 2010 Oct 15;248(2):156-64. doi: 10.1016/j.taap.2010.07.023. Epub 2010 Aug 5.
9
Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers.四环素及其类似物通过靶向寡聚物保护秀丽隐杆线虫免受β淀粉样蛋白诱导的毒性。
Neurobiol Dis. 2010 Nov;40(2):424-31. doi: 10.1016/j.nbd.2010.07.002. Epub 2010 Jul 14.
10
Probing the biology of Alzheimer's disease in mice.在小鼠中探究阿尔茨海默病的生物学。
Neuron. 2010 Jun 10;66(5):631-45. doi: 10.1016/j.neuron.2010.04.031.
Zotero 插件