Division of Clinical Pharmacology and Pediatric Toxicology, Vanderbilt University Medical Center, 11425 MRB IV, 2215-B Garland Ave., Nashville, TN 37232-0414, USA.
Metallomics. 2011 Mar;3(3):271-9. doi: 10.1039/c0mt00064g. Epub 2011 Jan 6.
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
神经退行性变的特征是神经元的死亡或结构和/或功能的丧失。许多神经退行性疾病，包括帕金森病（PD）和阿尔茨海默病（AD），都是神经退行性过程的结果。金属对于许多生命过程是必不可少的，但它们也是几种神经退行性机制的罪魁祸首。在这篇综述中，我们讨论了金属在神经退行性疾病中的作用，重点介绍了秀丽隐杆线虫（C. elegans）遗传模型在破译与 PD 和 AD 病因相关的机制方面的应用。
