The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Histol Histopathol. 2011 Mar;26(3):395-408. doi: 10.14670/HH-26.395.
The trans-Golgi network (TGN) is a major traffic hub of the cell, as it regulates membrane transport in the secretory pathway as well as receiving protein cargo by retrograde transport from endocytic compartments. Retrograde transport between endosomes and the TGN is essential for the recycling of membrane proteins which regulate a range of cellular and development functions. In addition, retrograde transport pathways are exploited by many bacterial toxins to mediate cytotoxicity and by some viral proteins to promote pathogenicity. Recent advances using a range of molecular cell biological strategies have identified multiple retrograde transport pathways each regulated by a distinct set of molecular machinery. Here we review recent advances in this field and highlight the importance of these transport pathways in a range of physiological processes.
反式高尔基体网络（TGN）是细胞的主要交通枢纽，因为它调节分泌途径中的膜运输，以及通过从内体逆转运接收蛋白质货物。内体和 TGN 之间的逆行运输对于调节多种细胞和发育功能的膜蛋白的再循环是必不可少的。此外，逆行运输途径被许多细菌毒素利用来介导细胞毒性，被一些病毒蛋白利用来促进致病性。最近使用一系列分子细胞生物学策略的进展已经确定了多个逆行运输途径，每个途径都由一组不同的分子机制调节。在这里，我们回顾了该领域的最新进展，并强调了这些运输途径在多种生理过程中的重要性。
