Chia Pei Zhi Cheryl, Gunn Priscilla, Gleeson Paul A
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Histochem Cell Biol. 2013 Sep;140(3):307-15. doi: 10.1007/s00418-013-1125-6. Epub 2013 Jul 14.
The retrograde membrane transport pathways from endosomes to the trans-Golgi network (TGN) are now recognized as critical intracellular pathways to recycle and shuttle a selective subgroup of membrane proteins, including sorting receptors, membrane-bound enzymes, transporters, as well as providing an avenue for the intracellular transport of various bacterial toxins. Multiple pathways from endosomes to the TGN have now been defined which differ between the cargo transported and the machinery used. Here, we review advances in these pathways and the requirement for TGN organization, and also discuss the development of unbiased analytical approaches to quantitatively track cargo that use these endosome-to-TGN pathways.
从内体到反式高尔基体网络（TGN）的逆向膜运输途径如今被认为是细胞内的关键途径，用于回收和转运膜蛋白的一个选择性亚组，包括分选受体、膜结合酶、转运蛋白，同时也为各种细菌毒素的细胞内运输提供了一条途径。现已确定了从内体到TGN的多种途径，这些途径在运输的货物和使用的机制方面存在差异。在此，我们综述了这些途径的进展以及TGN组织的要求，还讨论了用于定量追踪利用这些内体到TGN途径的货物的无偏差分析方法的发展。
