大戟花提取物的抗糖尿病和自由基清除潜力
Antidiabetic and Free Radicals Scavenging Potential of Euphorbia hirta Flower Extract.
作者信息
Kumar S, Malhotra R, Kumar D
机构信息
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136 119, India.
出版信息
Indian J Pharm Sci. 2010 Jul;72(4):533-7. doi: 10.4103/0250-474X.73921.
The present study was carried out to evaluate antidiabetic and in vitro free radicals scavenging effects of flower extract of Euphorbia hirta. The ethanolic and petroleum ether extracts (250 and 500 mg/kg) were orally tested for 21 days in alloxan induced diabetic mice and blood glucose level was measured with glucometer. Administration of extract resulted in significant reduction in serum cholesterol, triglycerides, creatinine, urea, alkaline phosphatase levels but high density lipoprotein levels and total proteins were found to be increased after treatments. Free radicals scavenging effect of ethanolic extract was also evaluated by various antioxidant assays, including 1, 1-diphenyl-2-picryl hydrazyl free radical scavenging activity, superoxide anion radical scavenging, nitric oxide scavenging, and reducing power assay. It was compared with standard antioxidants compounds such as butylated hydroxyl anisole and ascorbic acid. All the extracts showed antioxidant activity in all the tested methods.
本研究旨在评估大戟花提取物的抗糖尿病作用及体外自由基清除效果。将乙醇提取物和石油醚提取物（250和500毫克/千克）对四氧嘧啶诱导的糖尿病小鼠进行为期21天的口服试验，并用血糖仪测量血糖水平。提取物给药后，血清胆固醇、甘油三酯、肌酐、尿素、碱性磷酸酶水平显著降低，但治疗后高密度脂蛋白水平和总蛋白增加。还通过各种抗氧化试验评估了乙醇提取物的自由基清除效果，包括1,1-二苯基-2-苦基肼自由基清除活性、超氧阴离子自由基清除、一氧化氮清除和还原能力测定。并与丁基羟基茴香醚和抗坏血酸等标准抗氧化化合物进行了比较。所有提取物在所有测试方法中均表现出抗氧化活性。
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