Investigación y Desarrollo Biológicos, Laboratorio Centrovet, Santiago, Chile.
Vaccine. 2011 Mar 9;29(12):2336-40. doi: 10.1016/j.vaccine.2010.12.107. Epub 2011 Jan 8.
Effective oral immunization systems may be very helpful to the salmon industry, particularly during the seawater growth stages in which vaccination through injection is not possible. During the seawater growing stage, fish become more susceptible to several types of disease, due to the natural decay of vaccine-induced immune responses. In this study, we demonstrate the immune response and efficacy of a new salmonid rickettsial septicaemia (SRS) oral vaccine, developed using MicroMatrix™ Technology. The vaccine, which is administered together with daily feed ration, induces a specific immune response at local and systemic levels. Anti-Piscirickettsia salmonis specific antibodies were detected as soon as 300 degree-days after vaccination. Furthermore, oral vaccination was able to protect fish against a lethal pathogen challenge when administered either as a primary vaccination or as a booster for an injected vaccine. Results show that oral vaccination is an efficacious treatment for the prevention of SRS outbreaks throughout the salmon culture period.
有效的口服免疫体系可能对鲑鱼养殖业非常有帮助，尤其是在海水养殖阶段，此时通过注射进行接种是不可能的。在海水养殖阶段，由于疫苗诱导的免疫反应自然衰减，鱼类更容易受到多种疾病的影响。在这项研究中，我们展示了一种使用 MicroMatrix™ 技术开发的新型鲑鱼立克次氏体败血症（SRS）口服疫苗的免疫反应和效果。该疫苗与日常饲料一起给药，在局部和全身水平诱导特异性免疫反应。在接种后 300 个度日就可以检测到抗鲑鱼立克次氏体的特异性抗体。此外，口服接种可以保护鱼类免受致命病原体的攻击，无论是作为初次接种还是作为注射疫苗的加强针。结果表明，口服接种是预防鲑鱼养殖期 SRS 爆发的有效治疗方法。
