a Laboratorio de Inmunología Comparativa, Centro de Biotecnología Acuícola (CBA) , Universidad de Santiago de Chile , Santiago , Chile.
b Neisseria Research, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories , University of Southampton Faculty of Medicine , Southampton , UK.
Expert Rev Vaccines. 2017 Mar;16(3):215-228. doi: 10.1080/14760584.2017.1244483. Epub 2016 Oct 12.
Piscirickettsia salmonis (P. salmonis) is the aetiological bacterium of the contagious disease piscirickettsiosis or salmonid rickettsial septicaemia (SRS) and causes significant economic losses to aquaculture production in Chile. Current strategies to control infection are i) indiscriminate antibiotic use and ii) vaccination with predominantly P. salmonis bacterin vaccines that do not provide acceptable levels of protection against piscirickettsiosis. Areas covered: This review covers the basic biology of P. salmonis, clinical piscirickettsiosis and disease control, the development of current P. salmonis vaccines, innate and adaptive immunity and a 5-year plan to develop new piscirickettsiosis vaccines. Expert commentary: Fundamental knowledge is lacking on the complexities of P. salmonis-host interactions, relating to bacterial virulence and host innate and adaptive immune responses, which needs to be addressed. The development of new P. salmonis vaccines needs the application of comprehensive 'omics' technologies to identify candidate vaccine antigens capable of stimulating long-lasting protective immune responses.
鲑鱼鱼立克次体（Piscirickettsia salmonis，P. salmonis）是传染性鱼立克次体病或鲑鱼立克次体败血症（SRS）的病原体，给智利水产养殖生产造成了重大经济损失。目前控制感染的策略是：i）无差别使用抗生素和 ii）接种主要以 P. salmonis 菌体制成的疫苗，但这些疫苗不能提供对抗鱼立克次体病的可接受水平的保护。涵盖领域：本文综述了 P. salmonis 的基础生物学、临床鱼立克次体病和疾病控制、当前 P. salmonis 疫苗的开发、先天和适应性免疫以及开发新的鱼立克次体病疫苗的 5 年计划。专家评论：关于 P. salmonis-宿主相互作用的复杂性，包括细菌毒力和宿主先天和适应性免疫反应，基本知识还很缺乏，需要加以解决。开发新的 P. salmonis 疫苗需要应用全面的“组学”技术来识别有能力刺激持久保护免疫反应的候选疫苗抗原。
