Ponting G A, Ward H C, Halliday D, Sim A J
Academic Surgical Unit, St. Mary's Hospital, London, United Kingdom.
JPEN J Parenter Enteral Nutr. 1990 Sep-Oct;14(5):437-41. doi: 10.1177/0148607190014005437.
Our objective was to examine the effect of biosynthetic human growth hormone (BSHGH) on protein and energy metabolism in patients on full intravenous nutrition (IVN). Fifteen patients who had been established on IVN were allocated at random to receive either BSHGH (0.1 mg/kg/day) or placebo daily for 7 days. All patients received the same feeding regimen which contaminated 14 gN, 1000 kcal of glucose and 1000 kcal of fat (Intralipid) daily. The mean nitrogen balance for days 4 to 7 was significantly more positive with BSHGH (7.0 +/- 0.6 gN/day) than with placebo (4.4 +/- 0.7 gN/day). The BSHGH group were lighter (53 +/- 4.6 kg body weight) than controls (68 +/- 5.1 kg), but the difference was not significant. Resting energy expenditure (expressed as percentage of day 1) increased throughout the study in patients receiving BSHGH (day 7, 120.8 +/- 5.5%), whereas in patients receiving placebo it remained stable (day 7, 98.9 +/- 2.7%). The nonprotein respiratory quotients were similar for BSHGH (mean days 4-7, 0.94 +/- 0.04) and placebo (mean days 4-7, 0.93 +/- 0.01) (p greater than 0.05). This study demonstrates more positive nitrogen balance, which may in part be due to different substrate loads, and an increase in energy expenditure in patients receiving BSHGH.
我们的目的是研究生物合成人生长激素（BSHGH）对接受全静脉营养（IVN）患者蛋白质和能量代谢的影响。15名已接受IVN治疗的患者被随机分配，每天接受BSHGH（0.1mg/kg/天）或安慰剂，为期7天。所有患者均接受相同的喂养方案，每天提供14g氮、1000千卡葡萄糖和1000千卡脂肪（英脱利匹特）。第4至7天，接受BSHGH治疗患者的平均氮平衡（7.0±0.6g氮/天）显著优于接受安慰剂的患者（4.4±0.7g氮/天）。BSHGH组患者体重（53±4.6kg）比对照组（68±5.1kg）轻，但差异不显著。在整个研究过程中，接受BSHGH治疗的患者静息能量消耗（以第1天的百分比表示）增加（第7天，120.8±5.5%），而接受安慰剂的患者则保持稳定（第7天，98.9±2.7%）。BSHGH组（第4至7天平均值，0.94±0.04）和安慰剂组（第4至7天平均值，0.93±0.01）的非蛋白呼吸商相似（p>0.05）。本研究表明，接受BSHGH治疗的患者氮平衡更为正向，这可能部分归因于不同的底物负荷，以及能量消耗增加。
