Ponting G A, Halliday D, Teale J D, Sim A J
Academic Surgical Unit, St Mary's Hospital Medical School, London.
Lancet. 1988 Feb 27;1(8583):438-40. doi: 10.1016/s0140-6736(88)91232-9.
11 patients having major gastrointestinal surgery were allocated at random to receive either biosynthetic human growth hormone (BSHGH) 0.1 mg/kg or placebo daily for the first 7 postoperative days. All patients received the same intravenous feeding regimen, which contained 2.09 MJ glucose, 1.88 MJ fat, and 7 g N daily. Patients receiving BSHGH were in positive nitrogen balance throughout the study (mean 1.8 [SEM 0.4] g N/day) and those receiving placebo were in negative nitrogen balance (mean -0.9 [0.7] g N/day). Resting energy expenditure progressively increased in the patients receiving BSHGH (115.7% [14.8] on day 7) but remained unchanged in patients receiving placebo (99.35% [1.4]). Fat oxidation was nearly three times higher in the patients on BSHGH (4.09 [0.38] MJ/day) than in controls (1.38 [0.50]). Carbohydrate oxidation remained about the same in both groups. Whole-body protein turnover, synthesis, and breakdown were increased in the patients receiving growth hormone.
11例接受大型胃肠道手术的患者被随机分配，在术后的前7天，每天分别接受0.1mg/kg的生物合成人生长激素（BSHGH）或安慰剂治疗。所有患者均接受相同的静脉营养方案，该方案每天包含2.09兆焦耳葡萄糖、1.88兆焦耳脂肪和7克氮。在整个研究过程中，接受BSHGH的患者处于正氮平衡状态（平均每天1.8[标准误0.4]克氮），而接受安慰剂的患者处于负氮平衡状态（平均每天-0.9[0.7]克氮）。接受BSHGH的患者静息能量消耗逐渐增加（第7天为115.7%[14.8]），而接受安慰剂的患者静息能量消耗保持不变（99.35%[1.4]）。接受BSHGH的患者脂肪氧化量几乎是对照组的三倍（4.09[0.38]兆焦耳/天对1.38[0.50]）。两组的碳水化合物氧化量保持大致相同。接受生长激素的患者全身蛋白质周转率、合成率和分解率均增加。
