Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Dentistry Departament, State's University of Paraíba, Campina Grande, PB, Brazil.
Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1213-1217. doi: 10.1007/s00405-010-1472-z. Epub 2011 Jan 8.
The objective of this study was to assess angiogenic activity by analyzing anti-CD105 and anti-CD34 immunostaining in 20 cases of vascular malformations (VMs) and 20 cases of oral pyogenic granulomas (OPG). In addition, the usefulness of these markers for the differential diagnosis of these two oral tumors was evaluated. The results showed no significant difference in mean microvessel count between the anti-CD105 (P = 0.803) and anti-CD34 (P = 0.279) antibody. The mean number of vessels was 18.75 and 59.72 for oral VMs immunostained with anti-CD105 and anti-CD34 antibody, respectively, whereas in OPG the mean number was 20.22 and 48.09, respectively. CD34 was found to be more effective than CD105 in identifying blood vessels. However, the anti-CD105 antibody seems to be more related to vascular neoformation. Overall, this study supports the role of angiogenic factors in the etiopathogenesis of oral VMs and PG, but the results showed that quantification of angiogenesis cannot be used as a marker for the differential diagnosis of these two types of lesions.
本研究旨在通过分析 20 例血管畸形（VM）和 20 例口腔化脓性肉芽肿（OPG）中抗 CD105 和抗 CD34 免疫染色来评估血管生成活性。此外，还评估了这些标志物在这两种口腔肿瘤鉴别诊断中的有用性。结果显示，抗 CD105（P=0.803）和抗 CD34（P=0.279）抗体之间的微血管计数平均值无显著差异。抗 CD105 和抗 CD34 抗体免疫染色的口腔 VM 平均血管数分别为 18.75 和 59.72，而 OPG 中的平均血管数分别为 20.22 和 48.09。与 CD105 相比，CD34 更有效地识别血管。然而，抗 CD105 抗体似乎与血管新生更相关。总的来说，这项研究支持血管生成因子在口腔 VM 和 PG 的发病机制中的作用，但结果表明，血管生成的定量不能作为这两种病变鉴别诊断的标志物。
Zotero 插件