Chuang Hui-Ching, Su Chih-Ying, Huang Hsuang-Ying, Chien Chih-Yen, Chen Ching-Mei, Huang Chao-Cheng
Department of Otolaryngology, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Laryngoscope. 2006 Jul;116(7):1175-9. doi: 10.1097/01.mlg.0000224338.56902.28.
The purpose of this article is to investigate the expressions of vascular endothelial growth factor (VEGF) and endoglin (CD105) in the biopsy tissues of squamous cell carcinoma of the tongue in early tumor stages and their relationship with the clinicopathologic features.
The authors conducted retrospective clinical and biologic studies. Immunohistochemistry was used to study the expressions of VEGF and CD105 in the biopsy tissues taken from 94 patients with T1 and T2 tongue cancers. The expressions of VEGF and CD105 were analyzed and correlated to the clinicopathologic features of these patients.
High expressions of VEGF and CD105 significantly correlated with a relatively advanced tumor stage (P=.001 and P<.001), positive nodal status (P<.001 and P<.001), presence of tumor necrosis (P=.022 and P=.01), and greater tumor thickness (P<.001 and P<.001), respectively. In addition, high expression of CD105 correlated with the presence of perineural invasion (P=.003). However, the expression of VEGF and CD105 did not significantly correlate with age, gender, vascular invasion, or histologic grading. The cumulative 5-year disease-free survival rate significantly correlated with low expression of VEGF (P=.003), CD105 (P<.001), positive nodal status (P<.001), a relatively advanced tumor stage (P=.024), greater tumor thickness (P=.023), and presence of tumor necrosis (P=.003). Nonetheless, Cox's regression analysis revealed that only the expression of CD105 was an independent prognostic predictor for survival (P<.001).
Higher expression of either CD105 or VEGF in the tumor bed implicates a more aggressive potential for T1 and T2 tongue cancers, and the expression of CD105 is a useful predictive prognostic factor in early tongue cancer.
本文旨在研究血管内皮生长因子（VEGF）和内皮糖蛋白（CD105）在早期舌鳞状细胞癌活检组织中的表达情况及其与临床病理特征的关系。
作者进行了回顾性临床和生物学研究。采用免疫组织化学方法研究94例T1和T2期舌癌患者活检组织中VEGF和CD105的表达情况。分析VEGF和CD105的表达，并将其与这些患者的临床病理特征进行相关性分析。
VEGF和CD105的高表达分别与相对较晚的肿瘤分期（P = 0.001和P < 0.001）、阳性淋巴结状态（P < 0.001和P < 0.001）、肿瘤坏死的存在（P = 0.022和P = 0.01）以及更大的肿瘤厚度（P < 0.001和P < 0.001）显著相关。此外，CD105的高表达与神经周围浸润的存在相关（P = 0.003）。然而，VEGF和CD105的表达与年龄、性别、血管浸润或组织学分级无显著相关性。累积5年无病生存率与VEGF低表达（P = 0.003）、CD105低表达（P < 0.001）、阳性淋巴结状态（P < 0.001）、相对较晚的肿瘤分期（P = 0.024）、更大的肿瘤厚度（P = 0.023）以及肿瘤坏死的存在（P = 0.003）显著相关。尽管如此，Cox回归分析显示只有CD105的表达是生存的独立预后预测指标（P < 0.001）。
肿瘤床中CD105或VEGF的高表达提示T1和T2期舌癌具有更强的侵袭潜能，且CD105的表达是早期舌癌有用的预测预后因素。
