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本文引用的文献

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Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library.植物鞘氨醇所有立体异构体的发散合成及其在神经酰胺文库构建中的应用。
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Amphritea atlantica gen. nov., sp. nov., a gammaproteobacterium from the Logatchev hydrothermal vent field.大西洋安芙瑞氏菌属，新属，新种，一种来自洛加乔夫热液喷口场的γ-变形菌。
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A ceramide and cerebroside from the starfish asterias amurensis Lütken and their plant-growth promotion activities.来自多棘海盘车（Asterias amurensis Lütken）的一种神经酰胺和脑苷脂及其促进植物生长的活性。
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Promoting apoptosis as a strategy for cancer drug discovery.促进细胞凋亡作为癌症药物研发的一种策略。
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BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.对照中的仅BH3结构域蛋白：特异性调节MCL-1和BAK介导的细胞凋亡。
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A new solution for an old problem: the regiochemical distribution of the acyl chains in galactolipids can be established by electrospray ionization tandem mass spectrometry.一个老问题的新解决方案：半乳糖脂中酰基链的区域化学分布可通过电喷雾电离串联质谱法确定。
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深海热液喷口无脊椎动物贻贝（Bathymodiolus thermophilus）来源的鞘氨醇酰胺 A 和 B，神经酰胺衍生物。

Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus.

机构信息

Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901-8521, USA.

出版信息

J Nat Prod. 2011 Apr 25;74(4):842-6. doi: 10.1021/np100601w. Epub 2011 Jan 11.

DOI:10.1021/np100601w
PMID:21222464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3081957/
Abstract

Two ceramide derivatives, bathymodiolamides A (1) and B (2), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus thermophilus. The molecular structures of these compounds were determined using a combination of NMR spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed in a ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus.

摘要

两种神经酰胺衍生物，深海热液喷口无脊椎动物贻贝深海嗜热菌来源的浴油酰胺 A（1）和 B（2）被分离出来。这些化合物的分子结构是通过 NMR 光谱、质谱和化学降解的组合来确定的。在 ApopScreen 细胞凋亡诱导和潜在抗癌活性的基于细胞的筛选中评估了生物活性。据我们所知，这是来自海洋热液喷口贻贝深海嗜热菌的次级代谢产物的首次报道。