英国儿童癌症幸存者研究中的子代性别比例与性腺照射
Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study.
作者信息
Reulen R C, Zeegers M P, Lancashire E R, Winter D L, Hawkins M M
机构信息
Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
出版信息
Br J Cancer. 2007 May 7;96(9):1439-41. doi: 10.1038/sj.bjc.6603736. Epub 2007 Apr 10.
Abstract
We investigated offspring sex ratio among 6232 offspring born to 3218 survivors of childhood cancer in relation to therapeutic irradiation, and pooled our data with those from two other large-scale studies giving a total of 9685 offspring. Exposure to high-dose gonadal irradiation was not associated with a significant alteration in offspring sex ratio compared to low doses (men: P=0.58, women: P=0.66). There was also no evidence that the ratio varied with time since cancer diagnosis when comparing survivors treated with radiotherapy vs those without (men: P=0.51; women: P=0.46). This, the largest study to date, finds no evidence that exposure to radiation affects the offspring sex ratio among survivors of childhood cancer.
摘要
我们调查了3218名儿童癌症幸存者所生的6232名后代的性别比例与治疗性辐射的关系，并将我们的数据与另外两项大规模研究的数据合并，总计有9685名后代。与低剂量相比，高剂量性腺辐射暴露与后代性别比例的显著改变无关（男性：P = 0.58，女性：P = 0.66）。在比较接受放疗与未接受放疗的幸存者时，也没有证据表明该比例随癌症诊断后的时间而变化（男性：P = 0.51；女性：P = 0.46）。这项迄今为止最大规模的研究没有发现证据表明辐射暴露会影响儿童癌症幸存者的后代性别比例。
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