The Graduate School, Khon Kaen University, Thailand.
Acta Haematol. 2011;125(4):186-92. doi: 10.1159/000322666. Epub 2011 Jan 13.
The prevalence of adolescent anemia, iron deficiency and thalassemia were examined in 2 provinces of northeast Thailand. Blood specimens were collected from adolescent subjects aged 15-17 years in 2 areas; 185 (85 males and 100 females) in Mukdahan province and 313 (116 males and 197 females) in Roi-Et. RBC parameters, serum ferritin levels, Hb and DNA analyses for the identification of common thalassemia genes in Thailand were investigated. The prevalences of anemia were found to be 21.1% (8.1 in male and 13.0 in female) and 16.6% (8.9 in male and 7.7 in female) in Mukdahan and Roi-Et province, respectively. Iron deficiency was observed to be 24.3% in Mukdahan and 14.7% in Roi-Et. Various types of thalassemia were identified in 62.2 and 58.8% of the subject populations, respectively. The proportions of iron deficiency, thalassemia and combined thalassemia and iron deficiency among anemic subjects were 10.2, 53.8 and 30.8% in Mukdahan, and 7.7, 67.3 and 9.6% in Roi-Et. Hematological characteristics were analyzed and are presented. It is concluded that thalassemia and hemoglobinopathies rather than iron deficiency are major causes of adolescent anemia which should be taken into account in public health strategies for the control of anemia in the region.
本研究旨在调查泰国东北部 2 省青少年贫血、铁缺乏和地中海贫血的流行情况。分别采集来自穆达汉和叻丕省 15-17 岁青少年（男性 185 名，女性 100 名；男性 313 名，女性 197 名）的血样。检测 RBC 参数、血清铁蛋白水平、Hb 以及对泰国常见地中海贫血基因进行 DNA 分析。结果显示，穆达汉和叻丕省的贫血患病率分别为 21.1%（男性 8.1%，女性 13.0%）和 16.6%（男性 8.9%，女性 7.7%）。铁缺乏在穆达汉和叻丕省的患病率分别为 24.3%和 14.7%。62.2%和 58.8%的研究对象分别被确诊为各种类型的地中海贫血。在贫血患者中，铁缺乏、地中海贫血和地中海贫血合并铁缺乏的比例分别为穆达汉 10.2%、53.8%和 30.8%，叻丕 7.7%、67.3%和 9.6%。对血液学特征进行了分析并作了呈现。结论认为，在地中海贫血和血红蛋白病而不是铁缺乏症是导致该地区青少年贫血的主要原因，在制定该地区贫血防控公共卫生策略时应考虑到这一点。
