Sukrat Bunyarit, Sirichotiyakul Supatra
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Med Assoc Thai. 2006 Oct;89 Suppl 4:S142-6.
To determine the prevalence and causes of anemia during pregnancy in Maharaj Nakorn Chiang Mai Hospital.
The pregnant women were screened with hemoglobin, hematocrit, osmotic fragility test, hemoglobin E test and serology for hepatitis B, syphilis and HIV at first antenatal visit. In anemic cases, serum ferritin, serum iron/total iron binding capacity, or therapeutic trial with iron supplementation were performed to assess the iron status. The cases of abnormal thalassemia screening were followed by hemoglobin A2 level, PCR for alpha-1 (SEA type) and hemoglobin electrophoresis. Additional tests were stool exam, stool occult blood and red blood cell indices. Anemia was defined as a hemoglobin level less than 11.0 g/dl in the first and third trimester or less than 10.5 g/dl in the second trimester of pregnancy. The data was presented as mean, standard deviation and percentage.
Six hundred and forty eight pregnant women were recruited. The prevalence of anemia was 20.1 percent (128 cases). Classified in each trimester the prevalence was 17.3%, 23.8% and 50.0% in the first, second and third trimester, respectively. Thalassemia carriers and diseases were detected in 56 from 102 anemic pregnant women (54.9%). Iron status was assessed in 58 cases and iron deficiency anemia was found in 25 cases (43.1%). Other causes of anemia were parasitic infection (8.7%) and anemia of chronic disease (2.7%). In 37 anemic pregnant women (33.0%), the causes of anemia were not found.
The prevalence of anemia in pregnant women who first attended at the antenatal clinic was 20.1%. The main causes of anemia were thalassemia carriers/diseases and iron deficiency anemia.
确定清迈玛哈拉吉医院孕期贫血的患病率及病因。
孕妇在首次产前检查时接受血红蛋白、血细胞比容、渗透脆性试验、血红蛋白E检测以及乙肝、梅毒和艾滋病毒血清学检查。对于贫血病例，进行血清铁蛋白、血清铁/总铁结合力检测或铁补充治疗试验以评估铁状态。对异常地中海贫血筛查病例，进一步检测血红蛋白A2水平、α-1（SEA型）聚合酶链反应和血红蛋白电泳。其他检查包括粪便检查、粪便潜血和红细胞指数。贫血定义为妊娠第一和第三孕期血红蛋白水平低于11.0 g/dl，或妊娠第二孕期低于10.5 g/dl。数据以均值、标准差和百分比表示。
共招募648名孕妇。贫血患病率为20.1%（128例）。按各孕期分类，第一、第二和第三孕期的患病率分别为17.3%、23.8%和50.0%。102例贫血孕妇中有56例（54.9%）检测出地中海贫血携带者和疾病。对58例进行了铁状态评估，其中25例（43.1%）为缺铁性贫血。贫血的其他病因包括寄生虫感染（8.7%）和慢性病贫血（2.7%）。37例贫血孕妇（33.0%）未找到贫血病因。
首次到产前门诊就诊的孕妇贫血患病率为20.1%。贫血的主要病因是地中海贫血携带者/疾病和缺铁性贫血。
