Neuroglial Plasticity Laboratory at Department of Biochemistry, Postgraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Acta Odontol Scand. 2011 Jul;69(4):193-200. doi: 10.3109/00016357.2010.549505. Epub 2011 Jan 13.
Abstract Autism is a neurodevelopmental disorder characterized by impaired social interaction and restricted interests, compromised communication skills, and repetitive patterns of behavior. Both social and behavioral problems, which may include hyperactivity and quick frustration, may hinder the detection of other important pathologies such as orofacial pain. This is aggravated by the invasive nature of oral exploration, which may trigger violent and self-injurious responses, such as temper tantrums and/or head banging, which make the work of professionals extremely difficult during diagnoses, follow-up examinations, and dental treatments. In addition, mercury-containing amalgams used to treat dental caries (the most common form of acute orofacial pain) have been associated with higher rates of severe autism in children. The purpose of this review is to describe the current state of the art regarding the co-occurrence of orofacial pain and autism spectrum disorder, and how these conditions may interrelate clinically and neurobiologically.
摘要自闭症是一种神经发育障碍，其特征是社交互动受损和兴趣受限、沟通能力受损以及行为模式重复。社交和行为问题，包括多动和易激惹，可能会阻碍其他重要病理学的检测，如口腔疼痛。口腔探索的侵入性加剧了这种情况，可能会引发剧烈和自伤反应，如发脾气和/或头部撞击，这使得专业人员在诊断、随访检查和牙科治疗期间的工作变得极其困难。此外，用于治疗龋齿（最常见的急性口腔疼痛形式）的含汞汞合金与儿童中更严重的自闭症发生率较高有关。本综述的目的是描述口腔疼痛和自闭症谱系障碍共病的现状，以及这些疾病在临床和神经生物学上如何相互关联。
