炎症信号调节造血干细胞。
Inflammatory signals regulate hematopoietic stem cells.
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Trends Immunol. 2011 Feb;32(2):57-65. doi: 10.1016/j.it.2010.12.003. Epub 2011 Jan 11.
Abstract
Hematopoietic stem cells (HSCs) are the progenitors of all blood and immune cells, yet their role in immunity is not well understood. Most studies have focused on the ability of committed lymphoid and myeloid precursors to replenish immune cells during infection. Recent studies, however, have indicated that HSCs also proliferate in response to systemic infection and replenish effector immune cells. Inflammatory signaling molecules including interferons, tumor necrosis factor-α and Toll-like receptors are essential to the HSC response. Observing the biology of HSCs through the lens of infection and inflammation has led to the discovery of an array of immune-mediators that serve crucial roles in HSC regulation and function.
摘要
造血干细胞（HSCs）是所有血液和免疫细胞的祖细胞，但它们在免疫中的作用尚未得到很好的理解。大多数研究都集中在定向淋巴样和髓样前体细胞在感染期间补充免疫细胞的能力上。然而，最近的研究表明，HSCs 也可以响应全身感染而增殖，并补充效应免疫细胞。干扰素、肿瘤坏死因子-α 和 Toll 样受体等炎症信号分子是 HSC 反应所必需的。通过感染和炎症的视角观察 HSCs 的生物学特性，发现了一系列免疫介质，它们在 HSC 调节和功能中起着至关重要的作用。
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