Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
J Biochem. 2011 Mar;149(3):241-51. doi: 10.1093/jb/mvr002. Epub 2011 Jan 13.
Mitochondria are highly dynamic organelles that continuously change their shape through frequent fusion, fission and movement throughout the cell, and these dynamics are crucial for the life and death of the cells as they have been linked to apoptosis, maintenance of cellular homeostasis, and ultimately to neurologic disorders and metabolic diseases. Over the past decade, a growing number of novel proteins that regulate mitochondrial dynamics have been discovered. Large GTPase family proteins and their regulators control these aspects of mitochondrial dynamics. In this review, we briefly summarize the current knowledge about molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.
线粒体是高度动态的细胞器，通过在整个细胞中频繁的融合、裂变和运动不断改变其形状，这些动力学对于细胞的生死存亡至关重要，因为它们与细胞凋亡、细胞内稳态的维持以及最终的神经紊乱和代谢疾病有关。在过去的十年中，越来越多的调节线粒体动力学的新蛋白被发现。GTP 酶家族的大蛋白及其调节剂控制着线粒体动力学的这些方面。在这篇综述中，我们简要总结了调节线粒体融合/裂变的分子机制以及线粒体动力学在细胞病理生理学中的作用的最新知识。
